Browsing Harvard Medical School by Keyword "ulcerative colitis"

Now showing items 1-15 of 15

    • Amino Acid Position 11 of HLA-DRβ1 is a Major Determinant of Chromosome 6p Association with Ulcerative Colitis 

      Achkar, Jean-Paul; Klei, Lambertus; de Bakker, Paul I Wen; Bellone, Gaia; Rebert, Nancy; Scott, Regan; Lu, Ying; Regueiro, Miguel; Brzezinski, Aaron; Kamboh, M. Ilyas; Fiocchi, Claudio; Devlin, Bernie; Trucco, Massimo; Ringquist, Steven; Roeder, Kathryn; Duerr, Richard H (2012)
      The major histocompatibility complex (MHC) on chromosome 6p is an established risk locus for ulcerative colitis (UC) and Crohn’s disease (CD). We aimed to better define MHC association signals in UC and CD by combining ...

    • Biologic Concentration Testing in Inflammatory Bowel Disease 

      Vaughn, Byron P.; Sandborn, William J.; Cheifetz, Adam S. (Lippincott Williams & Wilkins, 2015)
      Abstract: Anti-TNF medications have revolutionized the care of patients with inflammatory bowel disease. However, despite an initial robust effect, loss of response is common and long-term results are disappointing. Much ...

    • CEACAM6 Gene Variants in Inflammatory Bowel Disease 

      Seiderer, Julia; Fries, Christoph; Tillack, Cornelia; Pfennig, Simone; Weidinger, Maria; Beigel, Florian; Lass, Ulrich; Wolf, Christiane; Lohse, Peter; Diegelmann, Julia; Czamara, Darina; Brand, Stephan; Glas, Jürgen; Göke, Burkhard; Ochsenkühn, Thomas; Müller-Myhsok, Bertram; Olszak, Torsten (Public Library of Science, 2011)
      Background: The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherentinvasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn’s disease (CD). Given ...

    • Characteristics of Inflammatory Bowel Disease Serology in Patients With Indeterminate Colitis 

      Sura, Siddharth P.; Ahmed, Awais; Cheifetz, Adam S.; Moss, Alan C (Ovid Technologies (Wolters Kluwer Health), 2014)
      Goals and Background Inflammatory bowel disease (IBD) serology testing is often used in patients with indeterminate colitis (IC) to help distinguish between ulcerative colitis (UC) and Crohn’s disease (CD). We investigated ...

    • Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features 

      Soucy, Genevieve; Wang, Helen; Farraye, Francis A; Schmidt, Jason F; Farris, Alton B; Lauwers, Gregory Y.; Cerda, Sandra R; Dendrinos, Kleanthis G; Odze, Robert D. (Springer Nature, 2011)
      Little is known regarding the clinical and, in particular, pathological manifestations of patients with isolated colonic Crohn's disease. The purpose of this study was to evaluate the clinical and pathological features of ...

    • An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas in the Setting of Colitis 

      Turker, N. Selcan; Heidari, Pedram; Kucherlapati, Raju; Kucherlapati, Melanie; Mahmood, Umar (Ivyspring International Publisher, 2014)
      Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes. We have developed an alternative EGFR-targeted PET imaging probe ...

    • Endogenous Levels of Circulating Androgens and Risk of Crohn's Disease and Ulcerative Colitis Among Women: A Nested Case–Control Study from the Nurses' Health Study Cohorts 

      Khalili, Hamed; Ananthakrishnan, Ashwin N.; Konijeti, Gauree G.; Higuchi, Leslie M.; Fuchs, Charles S.; Richter, James M.; Tworoger, Shelley S.; Hankinson, Susan E.; Chan, Andrew T. (Lippincott Williams & Wilkins, 2015)
      Background: Androgens, which are known to be altered by exogenous hormone use, have recently been linked to alterations of the gut microbiome and mucosal immune function. No study has evaluated the association between ...

    • Identification and Characterization of a Novel Association between Dietary Potassium and Risk of Crohn’s Disease and Ulcerative Colitis 

      Khalili, Hamed; Malik, Sakshi; Ananthakrishnan, Ashwin N.; Garber, John J.; Higuchi, Leslie M.; Joshi, Amit; Peloquin, Joanna; Richter, James M.; Stewart, Kathleen O.; Curhan, Gary C.; Awasthi, Amit; Yajnik, Vijay; Chan, Andrew T. (Frontiers Media S.A., 2016)
      Background: Recent animal studies have identified that dietary salt intake may modify the risk and progression of autoimmune disorders through modulation of the IL-23/TH17 pathway, which is critical in the pathogenesis of ...

    • Improving Case Definition of Crohnʼs Disease and Ulcerative Colitis in Electronic Medical Records Using Natural Language Processing 

      Ananthakrishnan, Ashwin; Cai, Tianxi; Savova, Guergana; Cheng, Su-Chun; Chen, Pei; Guzman, Raul; Gainer, Vivian S.; Murphy, Shawn; Szolovits, Peter; Xia, Zongqi; Shaw, Stanley; Churchill, Susanne; Karlson, Elizabeth; Kohane, Isaac; Plenge, Robert M.; Liao, Katherine (Oxford University Press (OUP), 2013-06)
      Introduction Prior studies identifying patients with inflammatory bowel disease (IBD) utilizing administrative codes have yielded inconsistent results. Our objective was to develop a robust electronic medical record (EMR) ...

    • Nephrolithiasis in patients with inflammatory bowel disease in the community 

      Cury, Dídia Bismara; Moss, Alan C; Schor, Nestor (Dove Medical Press, 2013)
      Background: Inflammatory bowel disease (IBD) has been associated with renal stone formation. The objective of this study was to determine prospectively the prevalence of nephrolithiasis in a community-based population of ...

    • Novel treatment options for ulcerative colitis 

      Vaughn, Byron P; Moss, Alan C (OMICS Publishing Group, 2013)
      The approved treatment options for patients with ulcerative colitis (UC) are currently limited to mesalamine or immunosuppressants. Patients who do not respond to mesalamine-based therapy can be treated with immunomodulators ...

    • Psychiatric Co-Morbidity Is Associated With Increased Risk of Surgery in Crohn's Disease 

      Ananthakrishnan, Ashwin N; Gainer, V. S.; Perez, R. G.; Cai, T.; Cheng, S.-C.; Savova, G.; Chen, P.; Szolovits, P.; Xia, Z.; De Jager, P. L.; Shaw, S. Y.; Churchill, S.; Karlson, E. W.; Kohane, I.; Perlis, R. H.; Plenge, R. M.; Murphy, S. N.; Liao, K. P. (Wiley-Blackwell, 2013)
      Introduction Psychiatric co-morbidity, in particular major depression and anxiety is common in patients with Crohn’s disease (CD) and ulcerative colitis (UC). Prior studies examining this may be confounded by the ...

    • The Role of Mesalamine in the Treatment of Ulcerative Colitis 

      Karagozian, Raffi; Burakoff, Robert (Dove Medical Press, 2007)
      Ulcerative colitis (UC) is a chronic inflammatory condition of unclear etiology affecting the large bowel, most commonly the rectum and extending proximally in a continuous fashion. The overall principle in the pathophysiolgy ...

    • Self-management in patients with inflammatory bowel disease: strategies, outcomes, and integration into clinical care 

      Plevinsky, Jill M; Greenley, Rachel N; Fishman, Laurie N (Dove Medical Press, 2016)
      Self-management, including medication adherence, is associated with improved health and outcomes for patients with inflammatory bowel disease. The concept of self-management is complex, but can be divided into those aspects ...

    • Serological Markers for Inflammatory Bowel Disease in AIDS Patients with Evidence of Microbial Translocation 

      Kamat, Anupa U; Ancuta, Petronela; Blumberg, Richard Steven; Gabuzda, Dana Helga (Public Library of Science, 2010)
      Background: Breakdown of the gut mucosal barrier during chronic HIV infection allows translocation of bacterial products such as lipopolysaccharides (LPS) from the gut into the circulation. Microbial translocation also ...