Browsing Harvard Medical School by Keyword "5-hydroxymethylcytosine"

Now showing items 1-5 of 5

    • 5-Hydroxymethylcytosine Expression in Metastatic Melanoma versus Nodal Nevus in Sentine Lymph Node Biopsies 

      Lee, Jonathan J.; Granter, Scott R.; Laga, Alvaro C.; Saavedra, Arturo; Zhan, Qian; Guo, Weimin; Xu, Shuyun; Murphy, George F.; Lian, Christine G. (2014)
      Sentinel lymph node biopsies are conducted to stage patients with newly-diagnosed melanomas that have histopathologic attributes conferring defined levels of metastatic potential. Because benign nevic cells may also form ...

    • Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming 

      Yamaguchi, Shinpei; Hong, Kwonho; Liu, Rui; Inoue, Azusa; Shen, Li; Zhang, Kun; Zhang, Yi (Nature Publishing Group, 2013)
      Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its ...

    • Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study 

      Sanchez-Guerra, Marco; Zheng, Yinan; Osorio-Yanez, Citlalli; Zhong, Jia; Chervona, Yana; Wang, Sheng; Chang, Dou; McCracken, John P; Díaz, Anaite; Bertazzi, Pier Alberto; Koutrakis, Petros; Kang, Choong-Min; Zhang, Xiao; Zhang, Wei; Byun, Hyang-Min; Schwartz, Joel; Hou, Lifang; Baccarelli, Andrea A (Taylor & Francis, 2015)
      Previous studies have reported epigenetic changes induced by environmental exposures. However, previous investigations did not distinguish 5-methylcytosine (5mC) from a similar oxidative form with opposite functions, ...

    • Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia 

      Wang, Xiu-Xia; Sun, Bao-Fa; Jiao, Jiao; Chong, Ze-Chen; Chen, Yu-Shen; Wang, Xiao-Li; Zhao, Yue; Zhou, Yi-Ming; Li, Da (Impact Journals LLC, 2015)
      Discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes has excited the field of epigenetics, but information on the genome-wide distribution of 5hmC is limited. Globozoospermia is a rare but severe cause of male ...

    • Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors 

      Larson, Allison R.; Dresser, Karen; Zhan, Qian; Lezcano, Cecilia; Woda, Bruce A.; Yosufi, Benafsha; Thompson, John F.; Scolyer, Richard A.; Mihm, Martin C.; Shi, Yujiang G.; Murphy, George F.; Lian, Christine Guo (2013)
      DNA methylation is the most well studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We ...