Browsing Harvard Medical School by Keyword "5-hydroxymethylcytosine"
Now showing items 1-5 of 5
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5-Hydroxymethylcytosine Expression in Metastatic Melanoma versus Nodal Nevus in Sentine Lymph Node Biopsies
(2014)Sentinel lymph node biopsies are conducted to stage patients with newly-diagnosed melanomas that have histopathologic attributes conferring defined levels of metastatic potential. Because benign nevic cells may also form ... -
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
(Nature Publishing Group, 2013)Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its ... -
Effects of particulate matter exposure on blood 5-hydroxymethylation: results from the Beijing truck driver air pollution study
(Taylor & Francis, 2015)Previous studies have reported epigenetic changes induced by environmental exposures. However, previous investigations did not distinguish 5-methylcytosine (5mC) from a similar oxidative form with opposite functions, ... -
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia
(Impact Journals LLC, 2015)Discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes has excited the field of epigenetics, but information on the genome-wide distribution of 5hmC is limited. Globozoospermia is a rare but severe cause of male ... -
Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors
(2013)DNA methylation is the most well studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We ...