Browsing Harvard Medical School by Keyword "Aβ"

Now showing items 1-3 of 3

    • The amyloid hypothesis of Alzheimer's disease at 25 years 

      Selkoe, Dennis J; Hardy, John (John Wiley and Sons Inc., 2016)
      Abstract Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 ...

    • Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo 

      An, Kyongman; Klyubin, Igor; Kim, Youngkyu; Jung, Jung Hoon; Mably, Alexandra J; O’Dowd, Sean T; Lynch, Timothy; Kanmert, Daniel; Lemere, Cynthia A; Finan, Gina M; Park, Joon Won; Kim, Tae-Wan; Walsh, Dominic M; Rowan, Michael J; Kim, Joung-Hun (BioMed Central, 2013)
      Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ). Despite their ...

    • Synaptotagmins interact with APP and promote Aβ generation 

      Gautam, Vivek; D’Avanzo, Carla; Berezovska, Oksana; Tanzi, Rudolph E.; Kovacs, Dora M. (BioMed Central, 2015)
      Background: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, ...