Now showing items 1-7 of 7

    • Co-Operative Additive Effects between HLA Alleles in Control of HIV-1 

      Matthews, Philippa C.; Listgarten, Jennifer; Carlson, Jonathan M.; Payne, Rebecca; Huang, Kuan-Hsiang Gary; Frater, John; Goedhals, Dominique; Steyn, Dewald; van Vuuren, Cloete; Paioni, Paolo; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger L.; Mncube, Zenele; Ndung'u, Thumbi; Walker, Bruce David; Heckerman, David; Goulder, Philip J. R. (Public Library of Science, 2012)
      Background: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I ...
    • A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition 

      Lutje Hulsik, David; Liu, Ying-ying; Strokappe, Nika M.; Battella, Simone; El Khattabi, Mohamed; McCoy, Laura E.; Sabin, Charles; Hinz, Andreas; Hock, Miriam; Macheboeuf, Pauline; Bonvin, Alexandre M. J. J.; Langedijk, Johannes P. M.; Davis, David; Forsman Quigley, Anna; Aasa-Chapman, Marlén M. I.; Seaman, Michael S.; Ramos, Alejandra; Poignard, Pascal; Favier, Adrien; Simorre, Jean-Pierre; Weiss, Robin A.; Verrips, C. Theo; Weissenhorn, Winfried; Rutten, Lucy (Public Library of Science, 2013)
      The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing ...
    • IFNγ Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I 

      Jehl, Stephanie P.; Nogueira, Catarina V.; Zhang, Xuqing; Starnbach, Michael N. (Public Library of Science, 2012)
      The activation of host cells by interferon gamma (IFNγ) is essential for inhibiting the intracellular replication of most microbial pathogens. Although significant advances have been made in identifying IFNγ-dependent host ...
    • Intradermal Immunization with Wall Teichoic Acid (WTA) Elicits and Augments an Anti-WTA IgG Response that Protects Mice from Methicillin-Resistant Staphylococcus aureus Infection Independent of Mannose-Binding Lectin Status 

      Takahashi, Kazue; Kurokawa, Kenji; Moyo, Patience; Jung, Dong-Jun; An, Jang-Hyun; Chigweshe, Lorencia; Paul, Elahna; Lee, Bok Luel (Public Library of Science, 2013)
      The objectives of this study were to investigate the immune response to intradermal immunization with wall teichoic acid (WTA) and the effect of MBL deficiency in a murine model of infection with methicillin-resistant ...
    • The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection 

      Ali, Youssif M.; Lynch, Nicholas J.; Haleem, Kashif S.; Fujita, Teizo; Endo, Yuichi; Hansen, Soren; Holmskov, Uffe; Takahashi, Kazue; Stahl, Gregory L.; Dudler, Thomas; Girija, Umakhanth V.; Wallis, Russell; Kadioglu, Aras; Stover, Cordula M.; Andrew, Peter W.; Schwaeble, Wilhelm J. (Public Library of Science, 2012)
      The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation. While there is limited information ...
    • Microbial Reprogramming Inhibits Western Diet-Associated Obesity 

      Poutahidis, Theofilos; Kleinewietfeld, Markus; Smillie, Christopher; Levkovich, Tatiana; Perrotta, Alison; Bhela, Siddheshvar; Varian, Bernard J.; Ibrahim, Yassin M.; Lakritz, Jessica R.; Kearney, Sean M.; Chatzigiagkos, Antonis; Hafler, David A.; Alm, Eric J.; Erdman, Susan E. (Public Library of Science, 2013)
      A recent epidemiological study showed that eating ‘fast food’ items such as potato chips increased likelihood of obesity, whereas eating yogurt prevented age-associated weight gain in humans. It was demonstrated previously ...
    • Runx1 and Runx3 Are Involved in the Generation and Function of Highly Suppressive IL-17-Producing T Regulatory Cells 

      Li, Lequn; Patsoukis, Nikolaos; Petkova, Victoria; Boussiotis, Vassiliki A. (Public Library of Science, 2012)
      CD4+Foxp3+ T regulatory cells (Tregs) display phenotypic and functional plasticity that is regulated by cytokines and other immune cells. Previously, we determined that during co-culture with CD4+CD25− T cells and antigen ...