Browsing Harvard Medical School by Keyword "Aging"

Now showing items 1-20 of 36

    • Age-related changes in early novelty processing as measured by ERPs 

      Riis, Jenna L.; Chong, Hyemi; McGinnnis, Scott; Tarbi, Elise; Sun, Xue; Holcomb, Phillip J.; Rentz, Dorene May; Daffner, Kirk R. (Elsevier BV, 2009)
      This study investigated age-related changes in the early processing of novel visual stimuli using ERPs. Well-matched old (n=30), middle-aged (n=30), and young (n=32) subjects were presented standard, target/rare, and ...

    • Age-Related Differences in Attention to Novelty Among Cognitively High Performing Adults 

      Daffner, Kirk R.; Ryan, Katherine K.; Williams, Danielle M.; Budson, Andrew E.; Rentz, Dorene May; Wolk, David A.; Holcomb, Phillip J.; Ryan, Katherine (Elsevier BV, 2006)
      Age-related differences in attention to novel events were studied in well-matched, cognitively high performing old, middle-aged and young subjects. Event-related potentials were recorded during a visual novelty oddball ...

    • Age-related differences in enhancement and suppression of neural activity underlying selective attention in matched young and old adults 

      Haring, A.E.; Zhuravleva, T.Y.; Alperin, B.R.; Rentz, Dorene May; Holcomb, P.J.; Daffner, Kirk R. (Elsevier BV, 2013)
      Selective attention reflects the top-down control of sensory processing that is mediated by enhancement or inhibition of neural activity. ERPs were used to investigate age-related differences in neural activity in an ...

    • Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes 

      Gladyshev, Vadim N. (John Wiley and Sons Inc., 2016)
      Summary Different theories posit that aging is caused by molecular damage, genetic programs, continued development, hyperfunction, antagonistic pleiotropy alleles, mutations, trade‐offs, incomplete repair, etc. Here, I ...

    • Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults 

      Ciesielski, Timothy; Bellinger, David C.; Schwartz, Joel David; Hauser, Russ B.; Wright, Robert O. (BioMed Central, 2013)
      Background: Low-level environmental cadmium exposure and neurotoxicity has not been well studied in adults. Our goal was to evaluate associations between neurocognitive exam scores and a biomarker of cumulative cadmium ...

    • Associations between Quantitative Mobility Measures Derived from Components of Conventional Mobility Testing and Parkinsonian Gait in Older Adults 

      Buchman, Aron S.; Leurgans, Sue E.; Weiss, Aner; VanderHorst, Veronique; Mirelman, Anat; Dawe, Robert; Barnes, Lisa L.; Wilson, Robert S.; Hausdorff, Jeffrey M.; Bennett, David A. (Public Library of Science, 2014)
      Objective: To provide objective measures which characterize mobility in older adults assessed in the community setting and to examine the extent to which these measures are associated with parkinsonian gait. Methods: During ...

    • Cancer survivor rehabilitation and recovery: Protocol for the Veterans Cancer Rehabilitation Study (Vet-CaRes) 

      Naik, Aanand D; Martin, Lindsey A; Karel, Michele J.; Wachen, Jennifer Schuster; Mulligan, Elizabeth Anne; Gosian, Jeffrey S; Herman, Levi Ian; Moye, Jennifer (BioMed Central, 2013)
      Background: Cancer survivors are a rapidly growing and aging population in the U.S., but there are many challenges associated with the survivorship experience such as functional disabilities and psychosocial distress. When ...

    • Characterizing Sympathetic Neurovascular Transduction in Humans 

      Tan, Can Ozan; Tamisier, Renaud; Hamner, J. W.; Taylor, John Andrew (Public Library of Science, 2013)
      Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses – sympathetic neurovascular transduction. ...

    • Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice 

      Zhang, Yiying; Shao, Haijun; Dong, Yuanlin; Swain, Celeste A; Yu, Buwei; Xia, Weiming; Xie, Zhongcong (BioMed Central, 2014)
      Alzheimer’s disease (AD) is the most common form of dementia. At the present time, however, AD still lacks effective treatments. Our recent studies showed that chronic treatment with anesthetic propofol attenuated brain ...

    • Comorbidity and Functional Trajectories From Midlife to Old Age: The Health and Retirement Study 

      Stenholm, Sari; Westerlund, Hugo; Head, Jenny; Hyde, Martin; Kawachi, Ichiro; Pentti, Jaana; Kivimäki, Mika; Vahtera, Jussi (Oxford University Press, 2014)
      Background. The number of diseases and physical functioning difficulties tend to increase with age. The aim of this study was to examine the trajectories of physical functioning across age groups and whether the trajectories ...

    • The Complexity of Standing Postural Control in Older Adults: A Modified Detrended Fluctuation Analysis Based upon the Empirical Mode Decomposition Algorithm 

      Zhou, Junhong; Manor, Bradley David; Liu, Dongdong; Hu, Kun; Zhang, Jue; Fang, Jing (Public Library of Science, 2013)
      Human aging into senescence diminishes the capacity of the postural control system to adapt to the stressors of everyday life. Diminished adaptive capacity may be reflected by a loss of the fractal-like, multiscale complexity ...

    • An epigenetic clock for gestational age at birth based on blood methylation data 

      Knight, Anna K.; Craig, Jeffrey M.; Theda, Christiane; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hansen, Christine S.; Hollegaard, Mads V.; Hougaard, David M.; Mortensen, Preben B.; Weinsheimer, Shantel M.; Werge, Thomas M.; Brennan, Patricia A.; Cubells, Joseph F.; Newport, D. Jeffrey; Stowe, Zachary N.; Cheong, Jeanie L. Y.; Dalach, Philippa; Doyle, Lex W.; Loke, Yuk J.; Baccarelli, Andrea A.; Just, Allan C.; Wright, Robert O.; Téllez-Rojo, Mara M.; Svensson, Katherine; Trevisi, Letizia; Kennedy, Elizabeth M.; Binder, Elisabeth B.; Iurato, Stella; Czamara, Darina; Räikkönen, Katri; Lahti, Jari M. T.; Pesonen, Anu-Katriina; Kajantie, Eero; Villa, Pia M.; Laivuori, Hannele; Hämäläinen, Esa; Park, Hea Jin; Bailey, Lynn B.; Parets, Sasha E.; Kilaru, Varun; Menon, Ramkumar; Horvath, Steve; Bush, Nicole R.; LeWinn, Kaja Z.; Tylavsky, Frances A.; Conneely, Karen N.; Smith, Alicia K. (BioMed Central, 2016)
      Background: Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately ...

    • ERP correlates of item recognition memory: Effects of age and performance 

      Wolk, David A.; Sen, N. Mandu; Chong, Hyemi; Riis, Jenna L.; McGinnis, Scott M.; Holcomb, Phillip J.; Daffner, Kirk R. (Elsevier BV, 2009)
      Decline in episodic memory is a common feature of healthy aging. Event-related potential (ERP) studies in young adults have consistently reported several modulations thought to index memory retrieval processes, but relatively ...

    • Executive Function and Falls in Older Adults: New Findings from a Five-Year Prospective Study Link Fall Risk to Cognition 

      Mirelman, Anat; Herman, Talia Nunes; Brozgol, Marina; Dorfman, Moran; Sprecher, Elliot; Schweiger, Avraham; Giladi, Nir; Hausdorff, Jeffrey M. (Public Library of Science, 2012)
      Background: Recent findings suggest that executive function (EF) plays a critical role in the regulation of gait in older adults, especially under complex and challenging conditions, and that EF deficits may, therefore, ...

    • The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates 

      Studenski, Stephanie A.; Peters, Katherine W.; Alley, Dawn E.; Cawthon, Peggy M.; McLean, Robert R.; Harris, Tamara B.; Ferrucci, Luigi; Guralnik, Jack M.; Fragala, Maren S.; Kenny, Anne M.; Kiel, Douglas P.; Kritchevsky, Stephen B.; Shardell, Michelle D.; Dam, Thuy-Tien L.; Vassileva, Maria T. (Oxford University Press, 2014)
      Background. Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based on clinically relevant ...

    • Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence 

      Wang, Meng C.; Oakley, Holly D.; Carr, Christopher E.; Sowa, Jessica N.; Ruvkun, Gary (Public Library of Science, 2014)
      Reproductive senescence is a hallmark of aging. The molecular mechanisms regulating reproductive senescence and its association with the aging of somatic cells remain poorly understood. From a full genome RNA interference ...

    • Healthy Older Adults Have Insufficient Hip Range of Motion and Plantar Flexor Strength to Walk Like Healthy Young Adults 

      Anderson, Dennis Earl; Madigan, Michael L. (Elsevier BV, 2014)
      Limited plantar flexor strength and hip extension range of motion (ROM) in older adults are believed to underlie common age-related differences in gait. However, no studies of age-related differences in gait have quantified ...

    • The impact of visual acuity on age-related differences in neural markers of early visual processing 

      Daffner, Kirk R.; Haring, Anna E.; Alperin, Brittany R.; Zhuravleva, Tatyana Y.; Mott, Katherine K.; Holcomb, Phillip J. (Elsevier BV, 2013)
      The extent to which age-related differences in neural markers of visual processing are influenced by changes in visual acuity has not been systematically investigated. Studies often indicate that their subjects had normal ...

    • Increased Early Processing of Task-Irrelevant Auditory Stimuli in Older Adults 

      Tusch, Erich S.; Alperin, Brittany R.; Holcomb, Phillip J.; Daffner, Kirk R. (Public Library of Science, 2016)
      The inhibitory deficit hypothesis of cognitive aging posits that older adults’ inability to adequately suppress processing of irrelevant information is a major source of cognitive decline. Prior research has demonstrated ...

    • An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology 

      Fernandes de Abreu, Diana Andrea; Caballero, Antonio; Fardel, Pascal; Stroustrup, Nicholas; Chen, Zhunan; Lee, KyungHwa; Keyes, William D.; Nash, Zachary M.; López-Moyado, Isaac F.; Vaggi, Federico; Cornils, Astrid; Regenass, Martin; Neagu, Anca; Ostojic, Ivan; Liu, Chang; Cho, Yongmin; Sifoglu, Deniz; Shen, Yu; Fontana, Walter; Lu, Hang; Csikasz-Nagy, Attila; Murphy, Coleen T.; Antebi, Adam; Blanc, Eric; Apfeld, Javier; Zhang, Yun; Alcedo, Joy; Ch'ng, QueeLim (Public Library of Science, 2014)
      Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse ...