Browsing Harvard Medical School by Keyword "Atherosclerosis"

Now showing items 1-20 of 29

    • AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis 

      Guo, Wen; Wong, Siu; Bhasin, Shalender (Public Library of Science, 2013)
      Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such ...

    • AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL 

      Isoda, Kikuo; Folco, Eduardo; Shimizu, Koichi; Libby, Peter (Elsevier BV, 2007)
      Background Previous reports have suggested that advanced glycation end products (AGE) participate in the pathogenesis of diabetic macroangiopathy. However, current understanding of the mechanisms by which AGE may accelerate ...

    • Association between dietary acid load and the risk of cardiovascular disease: nationwide surveys (KNHANES 2008–2011) 

      Han, Eugene; Kim, Gyuri; Hong, Namki; Lee, Yong-ho; Kim, Dong Woo; Shin, Hyun Joon; Lee, Byung-Wan; Kang, Eun Seok; Lee, In-Kyu; Cha, Bong-Soo (BioMed Central, 2016)
      Background: Acid–base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load and cardiovascular disease (CVD) risk in the general population ...

    • Atheromas that cause fatal thrombosis are usually large and frequently accompanied by vessel enlargement 

      Bezerra, Hiram Grando; Higuchi, Maria de Lourdes; Gutierrez, Paulo Sampaio; Palomino, Sueli Aparecida; Silvestre, Julia Maria La Chioma; Libby, Peter; Ramires, José Antonio Franchini (Elsevier BV, 2001)
      Several lines of clinical evidence show that AMI frequently occurs at sites with mild to moderate degree of coronary stenosis. The degree of luminal stenosis depends on plaque deposition and degree of vessel remodeling, ...

    • Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist 

      Elmariah, Sarina B.; Reddy, Vemuri B.; Lerner, Ethan A. (Public Library of Science, 2014)
      Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The ...

    • Characterization of smooth muscle-like cells in circulating human peripheral blood 

      Sugiyama, Seigo; Kugiyama, Kiyotaka; Nakamura, Shinichi; Kataoka, Keiichiro; Aikawa, Masanori; Shimizu, Koichi; Koide, Shunichi; Mitchell, Richard Neal; Ogawa, Hisao; Libby, Peter (Elsevier BV, 2006)
      Smooth muscle cells play an important role in human vascular diseases. Several lines of evidence demonstrate that circulating smooth muscle precursor cells contribute to intimal hyperplasia in animal models. We obtained ...

    • Effect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Rats 

      Lim, Soo; Shin, Hayley; Cho, Bong Jun; Ahn, Byung Yong; Kang, Seon Mee; Yoon, Ji Won; Jang, Hak Chul; Park, Kyong Soo; Choi, Sung Hee; Park, Ho Seon; Kim, Young-Bum (Public Library of Science, 2012)
      Background: Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in ...

    • Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial† 

      Tardif, Jean-Claude; Ballantyne, Christie M.; Barter, Philip; Dasseux, Jean-Louis; Fayad, Zahi A.; Guertin, Marie-Claude; Kastelein, John J. P.; Keyserling, Constance; Klepp, Heather; Koenig, Wolfgang; L'Allier, Philippe L.; Lespérance, Jacques; Lüscher, Thomas F.; Paolini, John F.; Tawakol, Ahmed; Waters, David D.; Pfeffer, M.; Brown, V.; Rouleau, J.; Watkins, P.; Wei, L.J.; Gosselin, G.; Chayer, C.; Lanthier, S.; Pelletier, G.B.; Racine, N.; Agarwal, H.; Brilakis, E.; Cannon, L.; Carrié, D.; Corbelli, J.; Coste, P.; de Winter, R.; Diaz, A.; Eisenberg, S.; Ennis, B.; Fajadet, J.; Fam, N.; Fortuin, D.; Gessler, C.; Grines, C.; Guerra, D.; Gum, H.; Haldis, T.; Heestermans, T.; Herrman, J.P.; Huynh, T.; Kedhi, E.; Koren, M.; Kouz, S.; Krolick, M.; Kumkumian, G.; Lavi, S.; Li, R.J.; Masud, ARZ; McAlhany, C.; McGrew, F.A.; O'Shaughnessy, C.; Oude Ophuis, A.J.M.; Parr, K.; Penny, W.; Pesant, Y.; Post, H.; Robinson, S.; Rodes-Cabau, J.; Roy, A.; Schulman, S.; Spence, F.; Stouffer, G.; Stys, T.; Sussex, B.; Tahirkheli, N.; Tardif, J-C.; Grégoire, J.; ten Berg, J.; van Boven, A.J.; von Birgelen, C.; Weinstein, D. (Oxford University Press, 2014)
      Aim High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies targeting HDL have failed to show benefits vs. placebo. Objective: To investigate the effects ...

    • Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography 

      Kashiwagi, Manabu; Liu, Linbo; Chu, Kengyeh K.; Sun, Chen-Hsin; Tanaka, Atsushi; Gardecki, Joseph A.; Tearney, Guillermo J. (Public Library of Science, 2014)
      The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that ...

    • The FReedom from Ischemic Events - New Dimensions for Survival (FRIENDS) registry: design of a prospective cohort study of patients with advanced peripheral artery disease 

      Keo, Hong H; Duval, Sue; Baumgartner, Iris; Oldenburg, Niki C; Jaff, Michael R; Goldman, JoAnne; Peacock, James M; Tretinyak, Alexander S; Henry, Timothy D; Luepker, Russell V; Hirsch, Alan T (BioMed Central, 2013)
      Background: Advanced lower extremity peripheral artery disease (PAD), whether presenting as acute limb ischemia (ALI) or chronic critical limb ischemia (CLI), is associated with high rates of cardiovascular ischemic events, ...

    • Genetics of coronary artery calcification among African Americans, a meta-analysis 

      Wojczynski, Mary K; Li, Mingyao; Bielak, Lawrence F; Kerr, Kathleen F; Reiner, Alex P; Wong, Nathan D; Yanek, Lisa R; Qu, Liming; White, Charles C; Lange, Leslie A; Ferguson, Jane F; He, Jing; Young, Taylor; Mosley, Thomas H; Smith, Jennifer A; Kral, Brian G; Guo, Xiuqing; Wong, Quenna; Ganesh, Santhi K; Heckbert, Susan R; Griswold, Michael E; O’Leary, Daniel H; Budoff, Matthew; Carr, J Jeffrey; Taylor,, Herman A; Bluemke, David A; Demissie, Serkalem; Hwang, Shih-Jen; Paltoo, Dina N; Polak, Joseph F; Psaty, Bruce M; Becker, Diane M; Province, Michael A; Post, Wendy S; O’Donnell, Christopher J; Wilson, James G; Harris, Tamara B; Kavousi, Maryam; Cupples, L Adrienne; Rotter, Jerome I; Fornage, Myriam; Becker, Lewis C; Peyser, Patricia A; Borecki, Ingrid B; Reilly, Muredach P (BioMed Central, 2013)
      Background: Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but ...

    • Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy 

      Shiffman, Dov; Trompet, Stella; Louie, Judy Z.; Rowland, Charles M.; Catanese, Joseph J.; Iakoubova, Olga A.; Kirchgessner, Todd G.; Westendorp, Rudi G. J.; de Craen, Anton J. M.; Slagboom, P. Eline; Buckley, Brendan M.; Stott, David J.; Sattar, Naveed; Devlin, James J.; Packard, Christopher J.; Ford, Ian; Jukema, J. Wouter; Sacks, Frank Martin (Public Library of Science, 2012)
      Statin therapy reduces the risk of coronary heart disease (CHD), however, the person-to-person variability in response to statin therapy is not well understood. We have investigated the effect of genetic variation on the ...

    • Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis 

      Isoda, Kikuo; Folco, Eduardo; Marwali, M. Reza; Ohsuzu, Fumitaka; Libby, Peter (Elsevier BV, 2008)
      Background Previous reports have suggested that levels of advanced glycation end product-modified LDL (AGE-LDL) increase in patients with diabetes due to elevated plasma glucose. However, understanding of the mechanisms ...

    • Hemoglobin A1c and Arterial and Ventricular Stiffness in Older Adults 

      Zieman, Susan J.; Kamineni, Aruna; Ix, Joachim H.; Barzilay, Joshua; Djoussé, Luc; Kizer, Jorge R.; Biggs, Mary L.; de Boer, Ian H.; Chonchol, Michel; Gottdiener, John S.; Selvin, Elizabeth; Newman, Anne B.; Kuller, Lewis H.; Siscovick, David S.; Mukamal, Kenneth J. (Public Library of Science, 2012)
      Objective: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. ...

    • High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPARγ/CD36 Pathway in Inflammatory Adipocytes 

      Zhong, Qiaoqing; Zhao, Shuiping; Yu, Bilian; Wang, Xing; Matyal, Robina; Li, Yunping; Jiang, Zhisheng (Ivyspring International Publisher, 2015)
      Aim: Previous studies have demonstrated that the dysregulated-secretion of adipokines by adipocytes may contribute to obesity-associated atherosclerosis (As) and high density lipoprotein (HDL) may protect against atherogenesis ...

    • Homocysteine and Carotid Plaque Stability: A Cross-Sectional Study in Chinese Adults 

      Yang, Xin; Zhou, Yong; Liu, Chao; Gao, Xiang; Wang, Anxin; Guo, Yuming; Li, Wen; Zhao, Xingquan; Liang, Wannian (Public Library of Science, 2014)
      Background and Purpose This study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability. Methods: A cross-sectional study was conducted from 2010 to 2011. A stratified random ...

    • Imaging of the unstable plaque: how far have we got? 

      Matter, Christian M.; Stuber, Matthias; Nahrendorf, Matthias (Oxford University Press, 2009)
      Rupture of unstable plaques may lead to myocardial infarction or stroke and is the leading cause of morbidity and mortality in western countries. Thus, there is a clear need for identifying these vulnerable plaques before ...

    • Independent Vascular and Cognitive Risk Factors for Postoperative Delirium 

      Rudolph, James; Jones, Richard Norman; Rasmussen, Lars S.; Silverstein, Jeffrey H.; Inouye, Sharon; Marcantonio, Edward Ralph (Elsevier BV, 2007)

    • Interaction between Obesity and the NFKB1 - 94ins/delATTG Promoter Polymorphism in Relation to Incident Acute Coronary Syndrome: A Follow Up Study in Three Independent Cohorts 

      Stegger, Jakob Gerhard; Schmidt, Erik Berg; Berentzen, Tina Landsvig; Tjønneland, Anne; Vogel, Ulla; Rimm, Eric B.; Sørensen, Thorkild I. A.; Overvad, Kim; Jensen, Majken Karoline (Public Library of Science, 2013)
      Introduction: The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the ...

    • Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions 

      Tang, E. H. C.; Shimizu, K.; Christen, T.; Rocha, V. Z.; Shvartz, E.; Tesmenitsky, Y.; Sukhova, Galina K.; Shi, Guo-Ping; Libby, Peter (Oxford University Press (OUP), 2010)
      Aim: Prostaglandin E2, by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. Thus, activation of EP4 may constitute an endogenous anti-inflammatory ...