Browsing Harvard Medical School by Keyword "Bacterial diseases"

Now showing items 1-4 of 4

    • Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth 

      Stanley, Sarah A.; Barczak, Amy K.; Silvis, Melanie R.; Luo, Samantha S.; Sogi, Kimberly; Vokes, Martha; Bray, Mark-Anthony; Carpenter, Anne E.; Moore, Christopher B.; Siddiqi, Noman; Rubin, Eric J.; Hung, Deborah T. (Public Library of Science, 2014)
      Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria are able to replicate intracellularly under certain conditions, ...

    • The Impact of Antimicrobial Resistance and Aging in VAP Outcomes: Experience from a Large Tertiary Care Center 

      Arvanitis, Marios; Anagnostou, Theodora; Kourkoumpetis, Themistoklis K.; Ziakas, Panayiotis D.; Desalermos, Athanasios; Mylonakis, Eleftherios (Public Library of Science, 2014)
      Background: Ventilator associated pneumonia (VAP) is a serious infection among patients in the intensive care unit (ICU). Methods: We reviewed the medical charts of all patients admitted to the adult intensive care units ...

    • NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus 

      Sharma, Onkar; O’Seaghdha, Maghnus; Velarde, Jorge J.; Wessels, Michael R. (Public Library of Science, 2016)
      A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence ...

    • Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus 

      Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Jayamani, Elamparithi; Kim, Younghoon; Larkins-Ford, Jonah; Conery, Annie; Ausubel, Frederick M.; Mylonakis, Eleftherios (Public Library of Science, 2014)
      Staphylococcus aureus, the leading cause of hospital-acquired infections in the United States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. aureus infection model was previously carried ...