Browsing Harvard Medical School by Keyword "Biomarker Epidemiology"

Now showing items 1-20 of 24

    • Association between Cutaneous Nevi and Breast Cancer in the Nurses' Health Study: A Prospective Cohort Study 

      Zhang, Mingfeng; Zhang, Xuehong; Qureshi, Abrar A.; Eliassen, A. Heather; Hankinson, Susan E.; Han, Jiali (Public Library of Science, 2014)
      Background: Cutaneous nevi are suggested to be hormone-related. We hypothesized that the number of cutaneous nevi might be a phenotypic marker of plasma hormone levels and predict subsequent breast cancer risk. Methods and ...

    • Biochemical Phenotypes to Discriminate Microbial Subpopulations and Improve Outbreak Detection 

      Galar, Alicia; Kulldorff, Martin; Rudnick, Wallis; O'Brien, Thomas F.; Stelling, John (Public Library of Science, 2013)
      Background: Clinical microbiology laboratories worldwide constitute an invaluable resource for monitoring emerging threats and the spread of antimicrobial resistance. We studied the growing number of biochemical tests ...

    • Blood-Based Biomarkers of Aggressive Prostate Cancer 

      Liong, Men Long; Lim, Chun Ren; Yang, Hengxuan; Chao, Samuel; Bong, Chin Wei; Leong, Wing Seng; Das, Prashanta Kumar; Loh, Chit Sin; Lau, Ban Eng; Yu, Choon Geok; Ooi, Edie Jian Jiek; Nam, Robert K.; Allen, Paul Denney; Steele, Graeme S.; Wassmann, Karl; Richie, Jerome Paul; Liew, Choong Chin (Public Library of Science, 2012)
      Purpose: Prostate cancer is a bimodal disease with aggressive and indolent forms. Current prostate-specific-antigen testing and digital rectal examination screening provide ambiguous results leading to both under-and ...

    • Development of a New Risk Score for Incident Type 2 Diabetes Using Updated Diagnostic Criteria in Middle-Aged and Older Chinese 

      Ye, Xingwang; Zong, Geng; Liu, Xin; Liu, Gang; Gan, Wei; Zhu, Jingwen; Lu, Ling; Sun, Liang; Li, Huaixing; Hu, Frank B.; Lin, Xu (Public Library of Science, 2014)
      Type 2 diabetes mellitus (T2DM) reaches an epidemic proportion among adults in China. However, no simple score has been created for the prediction of T2DM incidence diagnosed by updated criteria with hemoglobin A1c (HbA1c) ...

    • The Effects of Stress at Work and at Home on Inflammation and Endothelial Dysfunction 

      Non, Amy L.; Rimm, Eric B.; Kawachi, Ichiro; Rewak, Marissa A.; Kubzansky, Laura D. (Public Library of Science, 2014)
      This study examined whether stress at work and at home may be related to dysregulation of inflammation and endothelial function, two important contributors to the development of cardiovascular disease. In order to explore ...

    • Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer 

      Chen, Guo-lin; Miller, Gregory Michael (Public Library of Science, 2013)
      The repressor element silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice ...

    • Filter Paper Blood Spot Enzyme Linked Immunoassay for Insulin and Application in the Evaluation of Determinants of Child Insulin Resistance 

      Martin, Richard M.; Patel, Rita; Zinovik, Alexander; Kramer, Michael S.; Oken, Emily; Vilchuck, Konstantin; Bogdanovich, Natalia; Sergeichick, Natalia; Gunnarsson, Robert; Grufman, Lisa; Foo, Ying; Gusina, Nina (Public Library of Science, 2012)
      Background: In large-scale epidemiology, bloodspot sampling by fingerstick onto filter paper has many advantages, including ease and low costs of collection, processing and transport. We describe the development of an ...

    • Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study 

      Du, Mengmeng; Prescott, Jennifer; Cornelis, Marilyn; Hankinson, Susan Elizabeth; Giovannucci, Edward L.; Kraft, Phillip L.; De Vivo, Immaculata (Public Library of Science, 2013)
      Background: Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. ...

    • Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women 

      Prescott, Jennifer; Thompson, Deborah J.; Kraft, Peter; Chanock, Stephen J.; Audley, Tina; Brown, Judith; Leyland, Jean; Folkerd, Elizabeth; Doody, Deborah; Hankinson, Susan Elizabeth; Hunter, David J.; Jacobs, Kevin B.; Dowsett, Mitch; Cox, David G.; Easton, Douglas F.; De Vivo, Immaculata (Public Library of Science, 2012)
      Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker ...

    • Healthy Dietary Interventions and Lipoprotein (a) Plasma Levels: Results from the Omni Heart Trial 

      Haring, Bernhard; Wyler von Ballmoos, Moritz C.; Appel, Lawrence J.; Sacks, Frank M. (Public Library of Science, 2014)
      Background: Increased lipoprotein(a) [Lp(a)] levels are associated with atherosclerotic cardiovascular disease. Studies of dietary interventions on changes in Lp(a) are sparse. We aimed to compare the effects of three ...

    • Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women 

      Sun, Qi; Shi, Ling; Prescott, Jennifer; Chiuve, Stephanie Elizabeth; Hu, Frank B.; De Vivo, Immaculata; Stampfer, Meir; Franks, Paul W.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian (Public Library of Science, 2012)
      Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related ...

    • Hemoglobin A1c and Arterial and Ventricular Stiffness in Older Adults 

      Zieman, Susan J.; Kamineni, Aruna; Ix, Joachim H.; Barzilay, Joshua; Djoussé, Luc; Kizer, Jorge R.; Biggs, Mary L.; de Boer, Ian H.; Chonchol, Michel; Gottdiener, John S.; Selvin, Elizabeth; Newman, Anne B.; Kuller, Lewis H.; Siscovick, David S.; Mukamal, Kenneth J. (Public Library of Science, 2012)
      Objective: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. ...

    • Impact of the Adipokine Adiponectin and the Hepatokine Fetuin-A on the Development of Type 2 Diabetes: Prospective Cohort- and Cross-Sectional Phenotyping Studies 

      Stefan, Norbert; Sun, Qi; Fritsche, Andreas; Machann, Jürgen; Schick, Fritz; Gerst, Felicia; Jeppesen, Charlotte; Joost, Hans-Georg; Hu, Frank B.; Boeing, Heiner; Ullrich, Susanne; Häring, Hans-Ulrich; Schulze, Matthias B. (Public Library of Science, 2014)
      Background: Among adipokines and hepatokines, adiponectin and fetuin-A were consistently found to predict the incidence of type 2 diabetes, both by regulating insulin sensitivity. Objective: To determine to what extent ...

    • Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study 

      Jiang, Zhenghui Gordon; Mukamal, Kenneth; Tapper, Elliot; Robson, Simon C.; Tsugawa, Yusuke (Public Library of Science, 2014)
      Background: Dyslipidemia, typically recognized as high serum triglyceride, high low-density lipoprotein cholesterol (LDL-C) or low high-density lipoprotein cholesterol (HDL-C) levels, are associated with nonalcoholic fatty ...

    • Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea 

      Kaczmarek, Elzbieta; Bakker, Jessie P.; Clarke, Douglas N.; Csizmadia, Eva; Kocher, Olivier; Veves, Aristidis; Tecilazich, Francesco; O'Donnell, Christopher P.; Ferran, Christiane; Malhotra, Atul (Public Library of Science, 2013)
      Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ...

    • Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype 

      Agustí, Alvar; Edwards, Lisa D.; Rennard, Stephen I.; MacNee, William; Tal-Singer, Ruth; Miller, Bruce E.; Vestbo, Jørgen; Lomas, David A.; Calverley, Peter M. A.; Wouters, Emiel; Crim, Courtney; Yates, Julie C.; Coxson, Harvey O.; Bakke, Per; Mayer, Ruth J.; Silverman, Edwin Kepner; Celli, Bartolome R. (Public Library of Science, 2012)
      Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence ...

    • Plasma Concentrations of Soluble Endoglin versus Standard Evaluation in Patients with Suspected Preeclampsia 

      Rana, Sarosh; Cerdeira, Ana Sofia Teixeira de; Wenger, Julia; Salahuddin, Saira; Lim, Kee-Hak; Ralston, Steven Joseph; Thadhani, Ravi Ishwar; Karumanchi, Subbian Ananth (Public Library of Science, 2012)
      Background: The purpose of this study was to compare plasma soluble endoglin (sEng) levels with standard clinical evaluation or plasma levels of other angiogenic proteins [soluble fms-like tyrosine kinase 1 (sFlt1) and ...

    • Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial 

      Miyazaki, Tetsuro; Chiuve, Stephanie; Sacks, Frank M.; Ridker, Paul M.; Libby, Peter; Aikawa, Masanori (Public Library of Science, 2014)
      Chronic inflammation closely associates with obesity, metabolic syndrome, diabetes mellitus, and atherosclerosis. Evidence indicates that the immunomodulator pentraxin 3 (PTX3) may serve as a biomarker of these cardiometabolic ...

    • Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women 

      Nan, Hongmei; Giovannucci, Edward L.; Wu, Kana; Selhub, Jacob; Paul, Ligi; Rosner, Bernard Alfred; Fuchs, Charles Stewart; Cho, Eunyoung (Public Library of Science, 2013)
      Background: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. Methods: We evaluated the association between ...

    • Predicting the Severity and Prognosis of Trismus after Intensity-Modulated Radiation Therapy for Oral Cancer Patients by Magnetic Resonance Imaging 

      Hsieh, Li-Chun; Chen, John W.; Wang, Li-Ying; Tsang, Yuk-Ming; Shueng, Pei-Wei; Liao, Li-Jen; Lo, Wu-Chia; Lin, Yu-Chin; Tseng, Chien-Fu; Kuo, Ying-Shiung; Jhuang, Jie-Yang; Tien, Hui-Ju; Juan, Hsueh-Fen; Hsieh, Chen-Hsi (Public Library of Science, 2014)
      To develop magnetic resonance imaging (MRI) indicators to predict trismus outcome for post-operative oral cavity cancer patients who received adjuvant intensity-modulated radiation therapy (IMRT), 22 patients with oral ...