Browsing Harvard Medical School by Keyword "Calcium"
Now showing items 1-4 of 4
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Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
(2016)Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor ... -
Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies
(Springer Berlin Heidelberg, 2015)With more than 6,000 new pediatric patients with treatment-resistant nephrotic syndrome in the US each year alone, the unmet need for novel, podocyte-specific therapies is substantial. Recently, the established therapeutic ... -
Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study
(BioMed Central, 2014)Background: Moderate to severe premenstrual syndrome (PMS) affects 8–20 percent of premenopausal women. Previous studies suggest that high dietary vitamin D intake may reduce risk. However, vitamin D status is influenced ... -
Rewiring neuronal microcircuits of the brain via spine head protrusions-a role for synaptopodin and intracellular calcium stores
(BioMed Central, 2016)Neurological diseases associated with neuronal death are also accompanied by axonal denervation of connected brain regions. In these areas, denervation leads to a decrease in afferent drive, which may in turn trigger active ...