Browsing Harvard Medical School by Keyword "Carbohydrate Metabolism"

Now showing items 1-10 of 10

    • Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women 

      Liao, Shunyao; Liu, Yunqiang; Tan, Yuande; Gan, Lu; Mei, Jie; Song, Wenzhong; Chi, Shu; Dong, Xianjue; Chen, Xiaojuan; Deng, Shaoping (Public Library of Science, 2012)
      Background: This study aimed to explore the association of MTNR1B genetic variants with gestational plasma glucose homeostasis in pregnant Chinese women. Methods: A total of 1,985 pregnant Han Chinese women were recruited ...

    • Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study 

      Nowak, Christoph; Salihovic, Samira; Ganna, Andrea; Brandmaier, Stefan; Tukiainen, Taru; Broeckling, Corey D.; Magnusson, Patrik K.; Prenni, Jessica E.; Wang-Sattler, Rui; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Giedraitis, Vilmantas; Ärnlöv, Johan; Berne, Christian; Gieger, Christian; Ripatti, Samuli; Lind, Lars; Pedersen, Nancy L.; Sundström, Johan; Ingelsson, Erik; Fall, Tove (Public Library of Science, 2016)
      Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to ...

    • Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line 

      Lutz, Norbert W.; Banerjee, Pallavi; Wilson, Brian J.; Ma, Jie; Cozzone, Patrick J.; Frank, Markus H. (Public Library of Science, 2016)
      We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for ...

    • Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes 

      Tao, Rongya; Xiong, Xiwen; Harris, Robert A.; White, Morris F.; Dong, Xiaocheng C. (Public Library of Science, 2013)
      Pyruvate dehydrogenase kinases (PDK1-4) play a critical role in the inhibition of the mitochondrial pyruvate dehydrogenase complex especially when blood glucose levels are low and pyruvate can be conserved for gluconeogenesis. ...

    • HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells 

      Arreola, Alexandra; Cowey, C. Lance; Coloff, Jonathan L.; Rathmell, Jeffrey C.; Rathmell, W. Kimryn (Public Library of Science, 2014)
      Background: Hypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma. The relationship of these factors to ...

    • The Human Urine Metabolome 

      Bouatra, Souhaila; Aziat, Farid; Mandal, Rupasri; Guo, An Chi; Wilson, Michael R.; Knox, Craig; Bjorndahl, Trent C.; Krishnamurthy, Ramanarayan; Saleem, Fozia; Liu, Philip; Dame, Zerihun T.; Poelzer, Jenna; Huynh, Jessica; Yallou, Faizath S.; Psychogios, Nick; Dong, Edison; Bogumil, Ralf; Roehring, Cornelia; Wishart, David S. (Public Library of Science, 2013)
      Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex. However, this chemical ...

    • Identifying Metabolic Subpopulations from Population Level Mass Spectrometry 

      DeGennaro, Christine M.; Savir, Yonatan; Springer, Michael (Public Library of Science, 2016)
      Metabolism underlies many important cellular decisions, such as the decisions to proliferate and differentiate, and defects in metabolic signaling can lead to disease and aging. In addition, metabolic heterogeneity can ...

    • Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice 

      O’Donnell, Peter E.; Ye, Xiu Zhen; DeChellis, Melissa A.; Davis, Vannessa M.; Duan, Sheng Zhong; Mortensen, Richard M.; Milstone, David S. (Public Library of Science, 2016)
      Peroxisome proliferator activated receptor gamma (PPARγ) is a pleiotropic ligand activated transcription factor that acts in several tissues to regulate adipocyte differentiation, lipid metabolism, insulin sensitivity and ...

    • Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes 

      Ho, Jennifer E.; Larson, Martin G.; Ghorbani, Anahita; Cheng, Susan; Chen, Ming-Huei; Keyes, Michelle; Rhee, Eugene P.; Clish, Clary B.; Vasan, Ramachandran S.; Gerszten, Robert E.; Wang, Thomas J. (Public Library of Science, 2016)
      Background: Although obesity and cardiometabolic traits commonly overlap, underlying pathways remain incompletely defined. The association of metabolite profiles across multiple cardiometabolic traits may lend insights ...

    • Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA) 

      Chatterjee, Ranee; Zelnick, Leila; Mukamal, Kenneth J.; Nettleton, Jennifer A.; Kestenbaum, Bryan R.; Siscovick, David S.; Ix, Joachim H.; Tracy, Russell; Hoofnagle, Andrew N.; Svetkey, Laura P.; Edelman, David; de Boer, Ian H. (Public Library of Science, 2016)
      Background: Recent studies have found low-normal potassium (K) to be associated with increased diabetes risk. We sought to verify these associations in a multi-ethnic US cohort; and to determine if these associations extend ...