Browsing Harvard Medical School by Keyword "Cardiovascular Diseases"

Now showing items 1-11 of 11

    • Abnormal Calcium Handling and Exaggerated Cardiac Dysfunction in Mice with Defective Vitamin D Signaling 

      Choudhury, Sangita; Bae, Soochan; Ke, Qingen; Lee, Ji Yoo; Singh, Sylvia S.; St-Arnaud, René; del Monte, Federica; Kang, Peter M. (Public Library of Science, 2014)
      Aim Altered vitamin D signaling is associated with cardiac dysfunction, but the pathogenic mechanism is not clearly understood. We examine the mechanism and the role of vitamin D signaling in the development of cardiac ...

    • Aspirin for Primary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Controlled Trials and Subgroup Analysis by Sex and Diabetes Status 

      Xie, Manling; Shan, Zhilei; Zhang, Yan; Chen, Sijing; Yang, Wei; Bao, Wei; Rong, Ying; Yu, Xuefeng; Hu, Frank B.; Liu, Liegang (Public Library of Science, 2014)
      Objective: To evaluate the benefits and harms of aspirin for the primary prevention of CVD and determine whether the effects vary by sex and diabetes status. Methods: We searched Medline, Embase, and Cochrane databases for ...

    • The Association between Individual and Combined Components of Metabolic Syndrome and Chronic Kidney Disease among African Americans: The Jackson Heart Study 

      Mendy, Vincent L.; Azevedo, Mario J.; Sarpong, Daniel F.; Rosas, Sylvia E.; Ekundayo, Olugbemiga T.; Sung, Jung Hye; Bhuiyan, Azad R.; Jenkins, Brenda C.; Addison, Clifton (Public Library of Science, 2014)
      Introduction: Approximately 26.3 million people in the United States have chronic kidney disease and many more are at risk of developing the condition. The association between specific metabolic syndrome components and ...

    • Associations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Study 

      Mehta, Amar J.; Kloog, Itai; Zanobetti, Antonella; Coull, Brent A.; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (Public Library of Science, 2014)
      Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily ...

    • Cardiovascular Magnetic Resonance Imaging of Scar Development Following Pulmonary Vein Isolation: A Prospective Study 

      Hsing, Jeff; Peters, Dana C.; Knowles, Benjamin R.; Manning, Warren J.; Josephson, Mark E. (Public Library of Science, 2014)
      Aims Cardiovascular magnetic resonance (MR) provides non-invasive assessment of early (24-hour) edema and injury following pulmonary vein isolation (by ablation) and subsequent scar formation. We hypothesize that 24-hours ...

    • Drivers of the Sex Disparity in Statin Therapy in Patients with Coronary Artery Disease: A Cohort Study 

      Zhang, Huabing; Plutzky, Jorge; Shubina, Maria; Turchin, Alexander (Public Library of Science, 2016)
      Background: Women are less likely to be prescribed statins than men. Existing reports explain only a fraction of this difference. We conducted a study to identify factors that account for sex differences in statin therapy ...

    • Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium 

      Dehghan, Abbas; Bis, Joshua C.; White, Charles C.; Smith, Albert Vernon; Morrison, Alanna C.; Cupples, L. Adrienne; Trompet, Stella; Chasman, Daniel I.; Lumley, Thomas; Völker, Uwe; Buckley, Brendan M.; Ding, Jingzhong; Jensen, Majken K.; Folsom, Aaron R.; Kritchevsky, Stephen B.; Girman, Cynthia J.; Ford, Ian; Dörr, Marcus; Salomaa, Veikko; Uitterlinden, André G.; Eiriksdottir, Gudny; Vasan, Ramachandran S.; Franceschini, Nora; Carty, Cara L.; Virtamo, Jarmo; Demissie, Serkalem; Amouyel, Philippe; Arveiler, Dominique; Heckbert, Susan R.; Ferrières, Jean; Ducimetière, Pierre; Smith, Nicholas L.; Wang, Ying A.; Siscovick, David S.; Rice, Kenneth M.; Wiklund, Per-Gunnar; Taylor, Kent D.; Evans, Alun; Kee, Frank; Rotter, Jerome I.; Karvanen, Juha; Kuulasmaa, Kari; Heiss, Gerardo; Kraft, Peter; Launer, Lenore J.; Hofman, Albert; Markus, Marcello R. P.; Rose, Lynda M.; Silander, Kaisa; Wagner, Peter; Benjamin, Emelia J.; Lohman, Kurt; Stott, David J.; Rivadeneira, Fernando; Harris, Tamara B.; Levy, Daniel; Liu, Yongmei; Rimm, Eric B.; Jukema, J. Wouter; Völzke, Henry; Ridker, Paul M.; Blankenberg, Stefan; Franco, Oscar H.; Gudnason, Vilmundur; Psaty, Bruce M.; Boerwinkle, Eric; O'Donnell, Christopher J. (Public Library of Science, 2016)
      Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a ...

    • Is COPD a Progressive Disease? A Long Term Bode Cohort Observation 

      de-Torres, Juan P.; Marín, Jose M.; Pinto-Plata, Víctor; Divo, Miguel; Sanchez-Salcedo, Pablo; Zagaceta, Jorge; Zulueta, Javier J.; Berto, Juan; Cabrera, Carlos; Celli, Bartolome R.; Casanova, Ciro (Public Library of Science, 2016)
      Background: The Global Initiative for Obstructive Lung Diseases (GOLD) defines COPD as a disease that is usually progressive. GOLD also provides a spirometric classification of airflow limitation. However, little is known ...

    • Laser-Supported CD133+ Cell Therapy in Patients with Ischemic Cardiomyopathy: Initial Results from a Prospective Phase I Multicenter Trial 

      Assmann, Alexander; Heke, Michael; Kröpil, Patric; Ptok, Lena; Hafner, Dieter; Ohmann, Christian; Martens, Andreas; Karluß, Antje; Emmert, Maximilian Y.; Kutschka, Ingo; Sievers, Hans-Hinrich; Klein, Hans-Michael (Public Library of Science, 2014)
      Objectives: This study evaluates the safety, principal feasibility and restoration potential of laser-supported CD133+ intramyocardial cell transplantation in patients with ischemic cardiomyopathy. Methods: Forty-two ...

    • Prospective Associations of Coronary Heart Disease Loci in African Americans Using the MetaboChip: The PAGE Study 

      Franceschini, Nora; Hu, Yijuan; Reiner, Alex P.; Buyske, Steven; Nalls, Mike; Yanek, Lisa R.; Li, Yun; Hindorff, Lucia A.; Cole, Shelley A.; Howard, Barbara V.; Stafford, Jeanette M.; Carty, Cara L.; Sethupathy, Praveen; Martin, Lisa W.; Lin, Dan-Yu; Johnson, Karen C.; Becker, Lewis C.; North, Kari E.; Dehghan, Abbas; Bis, Joshua C.; Liu, Yongmei; Greenland, Philip; Manson, JoAnn E.; Maeda, Nobuyo; Garcia, Melissa; Harris, Tamara B.; Becker, Diane M.; O'Donnell, Christopher; Heiss, Gerardo; Kooperberg, Charles; Boerwinkle, Eric (Public Library of Science, 2014)
      Background: Coronary heart disease (CHD) is a leading cause of morbidity and mortality in African Americans. However, there is a paucity of studies assessing genetic determinants of CHD in African Americans. We examined ...

    • Whole Blood Gene Expression and Atrial Fibrillation: The Framingham Heart Study 

      Lin, Honghuang; Yin, Xiaoyan; Lunetta, Kathryn L.; Dupuis, Josée; McManus, David D.; Lubitz, Steven A.; Magnani, Jared W.; Joehanes, Roby; Munson, Peter J.; Larson, Martin G.; Levy, Daniel; Ellinor, Patrick T.; Benjamin, Emelia J. (Public Library of Science, 2014)
      Background: Atrial fibrillation (AF) involves substantial electrophysiological, structural and contractile remodeling. We hypothesize that characterizing gene expression might uncover important pathways related to AF. ...