Browsing Harvard Medical School by Keyword "Caspase-1"

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    • Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection 

      Lupfer, Christopher; Thomas, Paul G.; Anand, Paras K.; Vogel, Peter; Milasta, Sandra; Martinez, Jennifer; Huang, Gonghua; Green, Maggie; Kundu, Mondira; Chi, Hongbo; Xavier, Ramnik J.; Green, Douglas R.; Lamkanfi, Mohamed; Dinarello, Charles A.; Doherty, Peter C.; Kanneganti, Thirumala-Devi (2013)
      NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-κB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been addressed. We demonstrate that ...