Browsing Harvard Medical School by Keyword "Cell Biology of Disease"
Now showing items 1-2 of 2
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FUS is sequestered in nuclear aggregates in ALS patient fibroblasts
(The American Society for Cell Biology, 2014)Mutations in the RNA-binding protein FUS have been shown to cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We investigate whether mutant FUS protein in ALS patient–derived fibroblasts affects ... -
Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma
(The American Society for Cell Biology, 2015)The receptor tyrosine kinase Axl has been described as an oncogene, and its deregulation has been implicated in the progression of several human cancers. While the role of Axl in esophageal adenocarcinoma has been addressed, ...