Browsing Harvard Medical School by Keyword "JQ1"

Now showing items 1-5 of 5

    • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition 

      Tang, Yujie; Gholamin, Sharareh; Schubert, Simone; Willardson, Minde I.; Lee, Alex; Bandopadhayay, Pratiti; Bergthold, Guillame; Masoud, Sabran; Nguyen, Brian; Vue, Nujsaubnusi; Balansay, Brianna; Yu, Furong; Oh, Sekyung; Woo, Pamelyn; Chen, Spenser; Ponnuswami, Anitha; Monje, Michelle; Atwood, Scott X.; Whitson, Ramon J.; Mitra, Siddhartha; Cheshier, Samuel H.; Qi, Jun; Beroukhim, Rameen; Tang, Jean Y.; Wechsler-Reya, Rob; Oro, Anthony E.; Link, Brian A.; Bradner, James E.; Cho, Yoon-Jae (2014)
      Hedgehog signaling drives oncogenesis in several cancers and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened. However, resistance to Smoothened inhibitors occurs via ...

    • Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia 

      Wedeh, Ghaith; Cerny-Reiterer, Sabine; Eisenwort, Gregor; Hermann, Harald; Blatt, Katharina; Hadzijusufovic, Emir; Sadovnik, Irina; Müllauer, Leonhard; Schwaab, Juliana; Hoffmann, Thomas; Bradner, James Elliott; Radia, Deepti; Sperr, Wolfgang R.; Hoermann, Gregor; Reiter, Andreas; Horny, Hans-Peter; Zuber, Johannes; Arock, Michel; Valent, Peter (Nature Publishing Group, 2015)
      Advanced systemic mastocytosis (SM) is a life-threatening neoplasm characterized by uncontrolled growth and accumulation of neoplastic mast cells (MCs) in various organs and a poor survival. So far, no curative treatment ...

    • Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) 

      Herrmann, Harald; Blatt, Katharina; Shi, Junwei; Gleixner, Karoline V.; Cerny-Reiterer, Sabine; Müllauer, Leonhard; Vakoc, Christopher R.; Sperr, Wolfgang R.; Horny, Hans-Peter; Bradner, James E.; Zuber, Johannes; Valent, Peter (Impact Journals LLC, 2012)
      Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled proliferation and accumulation of myeloblasts. Using an advanced RNAi screen-approach in an AML mouse model we have recently ...

    • Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression 

      Li, Gong-Quan; Guo, Wen-Zhi; Zhang, Yi; Seng, Jing-Jing; Zhang, Hua-Peng; Ma, Xiu-Xian; Zhang, Gong; Li, Jie; Yan, Bing; Tang, Hong-Wei; Li, Shan-Shan; Wang, Li-Dong; Zhang, Shui-Jun (Impact Journals LLC, 2016)
      Bromodomain 4 (BRD4) is an epigenetic regulator that, when inhibited, has anti-cancer effects. In this study, we investigated whether BRD4 could be a target for treatment of human hepatocellular carcinoma (HCC). We show ...

    • Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1 

      Jacques, Camille; Lamoureux, François; Baud’huin, Marc; Calleja, Lidia Rodriguez; Quillard, Thibaut; Amiaud, Jérôme; Tirode, Franck; Rédini, Françoise; Bradner, James E.; Heymann, Dominique; Ory, Benjamin (Impact Journals LLC, 2016)
      Ewing Sarcoma is a rare bone and soft tissue malignancy affecting children and young adults. Chromosomal translocations in this cancer produce fusion oncogenes as characteristic molecular signatures of the disease. The ...