Browsing Harvard Medical School by Keyword "R-roscovitine"

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    • Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis 

      Murphy, Á. C.; Weyhenmeyer, B.; Noonan, J.; Kilbride, S. M.; Schimansky, S.; Loh, K. P.; Kögel, D.; Letai, A. G.; Prehn, J. H. M.; Murphy, B. M. (Springer US, 2013)
      Glioblastoma (GBM) is the most aggressive form of primary brain tumour, with dismal patient outcome. Treatment failure is associated with intrinsic or acquired apoptosis resistance and the presence of a highly tumourigenic ...