Browsing Harvard Medical School by Keyword "Zoonoses"

Now showing items 1-12 of 12

    • Digital Surveillance: A Novel Approach to Monitoring the Illegal Wildlife Trade 

      Sonricker Hansen, Amy L.; Li, Annie; Joly, Damien; Mekaru, Sumiko; Brownstein, John Samuel (Public Library of Science, 2012)
      A dearth of information obscures the true scale of the global illegal trade in wildlife. Herein, we introduce an automated web crawling surveillance system developed to monitor reports on illegally traded wildlife. A ...

    • Effectiveness of Insecticide Spraying and Culling of Dogs on the Incidence of Leishmania infantum Infection in Humans: A Cluster Randomized Trial in Teresina, Brazil 

      Werneck, Guilherme L.; Costa, Carlos H. N.; de Carvalho, Fernando Aécio Amorim; Pires e Cruz, Maria do Socorro; Maguire, James H.; Castro, Marcia C. (Public Library of Science, 2014)
      Background: To evaluate the effect of insecticide spraying for vector control and elimination of infected dogs on the incidence of human infection with L. infantum, a randomized community intervention trial was carried out ...

    • Evaluation of Epidemic Intelligence Systems Integrated in the Early Alerting and Reporting Project for the Detection of A/H5N1 Influenza Events 

      Barboza, Philippe; Vaillant, Laetitia; Mawudeku, Abla; Nelson, Noele P.; Hartley, David M.; Madoff, Lawrence C.; Linge, Jens P.; Collier, Nigel; Brownstein, John Samuel; Yangarber, Roman; Astagneau, Pascal (Public Library of Science, 2013)
      The objective of Web-based expert epidemic intelligence systems is to detect health threats. The Global Health Security Initiative (GHSI) Early Alerting and Reporting (EAR) project was launched to assess the feasibility ...

    • Factors Influencing Performance of Internet-Based Biosurveillance Systems Used in Epidemic Intelligence for Early Detection of Infectious Diseases Outbreaks 

      Barboza, Philippe; Vaillant, Laetitia; Le Strat, Yann; Hartley, David M.; Nelson, Noele P.; Mawudeku, Abla; Madoff, Lawrence C.; Linge, Jens P.; Collier, Nigel; Brownstein, John S.; Astagneau, Pascal (Public Library of Science, 2014)
      Background: Internet-based biosurveillance systems have been developed to detect health threats using information available on the Internet, but system performance has not been assessed relative to end-user needs and ...

    • A Fit-Fat Index for Predicting Incident Diabetes in Apparently Healthy Men: A Prospective Cohort Study 

      Sloan, Robert A; Haaland, Benjamin A; Sawada, Susumu S; Lee, I-Min; Sui, Xuemei; Lee, Duck-chul; Ridouane, Yassine; Müller-Riemenschneider, Falk; Blair, Steven N (Public Library of Science, 2016)
      Background: The purpose of this study was to examine the impact of combined cardiorespiratory fitness and waist-to-height ratio in the form of a fit-fat index on incident diabetes risk. Additionally, the independent ...

    • Inferring Carbon Sources from Gene Expression Profiles Using Metabolic Flux Models 

      Brandes, Aaron; Lun, Desmond S.; Ip, Kuhn; Zucker, Jeremy Daniel Hofeld; Colijn, Caroline; Weiner, Brian; Galagan, James E. (Public Library of Science, 2012)
      Background: Bacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression ...

    • Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells 

      Pettengill, Matthew A; Lam, Verissa W.; Ollawa, Ikechukwu; Marques-da-Silva, Camila; Ojcius, David M. (Public Library of Science, 2012)
      Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown ...

    • Lassa Fever in Post-Conflict Sierra Leone 

      Shaffer, Jeffrey G.; Grant, Donald S.; Schieffelin, John S.; Boisen, Matt L.; Goba, Augustine; Hartnett, Jessica N.; Levy, Danielle C.; Yenni, Rachael E.; Moses, Lina M.; Fullah, Mohammed; Momoh, Mambo; Fonnie, Mbalu; Fonnie, Richard; Kanneh, Lansana; Koroma, Veronica J.; Kargbo, Kandeh; Ottomassathien, Darin; Muncy, Ivana J.; Jones, Abigail B.; Illick, Megan M.; Kulakosky, Peter C.; Haislip, Allyson M.; Bishop, Christopher M.; Elliot, Deborah H.; Brown, Bethany L.; Zhu, Hu; Hastie, Kathryn M.; Andersen, Kristian G.; Gire, Stephen K.; Tabrizi, Shervin; Tariyal, Ridhi; Stremlau, Mathew; Matschiner, Alex; Sampey, Darryl B.; Spence, Jennifer S.; Cross, Robert W.; Geisbert, Joan B.; Folarin, Onikepe A.; Happi, Christian T.; Pitts, Kelly R.; Geske, F. Jon; Geisbert, Thomas W.; Saphire, Erica Ollmann; Robinson, James E.; Wilson, Russell B.; Sabeti, Pardis C.; Henderson, Lee A.; Khan, S. Humarr; Bausch, Daniel G.; Branco, Luis M.; Garry, Robert F. (Public Library of Science, 2014)
      Background: Lassa fever (LF), an often-fatal hemorrhagic disease caused by Lassa virus (LASV), is a major public health threat in West Africa. When the violent civil conflict in Sierra Leone (1991 to 2002) ended, an ...

    • Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors 

      Brudner, Matthew; Karpel, Marshall; Lear, Calli; Chen, Li; Yantosca, L. Michael; Scully, Corinne; Sarraju, Ashish; Sokolovska, Anna; Zariffard, M. Reza; Eisen, Damon P.; Mungall, Bruce A.; Kotton, Darrell N.; Omari, Amel; Huang, I-Chueh; Farzan, Michael; Takahashi, Kazue; Stuart, Lynda; Stahl, Gregory L.; Ezekowitz, Alan B.; Spear, Gregory T.; Olinger, Gene G.; Schmidt, Emmett V.; Michelow, Ian C. (Public Library of Science, 2013)
      Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and ...

    • Modeling to Predict Cases of Hantavirus Pulmonary Syndrome in Chile 

      Nsoesie, Elaine O.; Mekaru, Sumiko R.; Ramakrishnan, Naren; Marathe, Madhav V.; Brownstein, John S. (Public Library of Science, 2014)
      Background: Hantavirus pulmonary syndrome (HPS) is a life threatening disease transmitted by the rodent Oligoryzomys longicaudatus in Chile. Hantavirus outbreaks are typically small and geographically confined. Several ...

    • NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus 

      Sharma, Onkar; O’Seaghdha, Maghnus; Velarde, Jorge J.; Wessels, Michael R. (Public Library of Science, 2016)
      A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence ...

    • Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein 

      Rajsbaum, Ricardo; Albrecht, Randy A.; Wang, May K.; Maharaj, Natalya P.; Versteeg, Gijs A.; Nistal-Villán, Estanislao; García-Sastre, Adolfo; Gack, Michaela U. (Public Library of Science, 2012)
      Influenza A viruses can adapt to new host species, leading to the emergence of novel pathogenic strains. There is evidence that highly pathogenic viruses encode for non-structural 1 (NS1) proteins that are more efficient ...