Browsing Harvard Medical School by Keyword "adenosine receptors"
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Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
(Taylor & Francis, 2015)Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited ...