Browsing Harvard Medical School by Keyword "anatomy"

Now showing items 1-10 of 10

    • Age at Developmental Cortical Injury Differentially Alters Corpus Callosum Volume in the Rat 

      Threlkeld, Steven W; Rosen, Glenn David; Fitch, R. Holly (BioMed Central, 2007)
      Background: Freezing lesions to developing rat cortex induced between postnatal day (P) one and three (P1 – 3) lead to malformations similar to human microgyria, and further correspond to reductions in brain weight and ...

    • Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data 

      Klerman, Hadassa; St. Hilaire, Melissa A.; Gronfier, Claude; Santhi, Nayantara; Kronauer, Richard E.; Gooley, Joshua James; Hull, Joseph Thomas; Lockley, Steven Ward; Wang, Wei; Klerman, Elizabeth Beryl (Public Library of Science, 2012)
      Accurate determination of circadian phase is necessary for research and clinical purposes because of the influence of the master circadian pacemaker on multiple physiologic functions. Melatonin is presently the most accurate ...

    • Assessing Murine Resistance Artery Function Using Pressure Myography 

      Shahid, Mohd; Buys, Emmanuel (MyJove Corporation, 2013)
      Pressure myograph systems are exquisitely useful in the functional assessment of small arteries, pressurized to a suitable transmural pressure. The near physiological condition achieved in pressure myography permits in-depth ...

    • CIP2A Promotes Proliferation of Spermatogonial Progenitor Cells and Spermatogenesis in Mice 

      Ventelä, Sami; Côme, Christophe; Mäkelä, Juho-Antti; Hobbs, Robin M.; Mannermaa, Leni; Kallajoki, Markku; Chan, Edward K.; Pandolfi, Pier Paolo; Toppari, Jorma; Westermarck, Jukka (Public Library of Science, 2012)
      Protein phosphatase 2A (PP2A) is a critical regulator of protein serine/threonine phosphorylation. However, the physiological and developmental roles of different PP2A complexes are very poorly understood. Here, we show ...

    • Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes 

      Costantino, Cristina Maria; Spooner, Eric; Ploegh, Hidde L.; Hafler, David A. (Public Library of Science, 2012)
      Human CD4\(^+\) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound ...

    • Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells 

      Rice, William; Zhang, Yan; Chen, Ying; Matsuzaki, Toshiyuki; Brown, Dennis; Lu, Hua A Jenny (Public Library of Science, 2012)
      The kidney maintains water homeostasis by modulating aquaporin 2 (AQP2) on the plasma membrane of collecting duct principal cells in response to vasopressin (VP). VP mediated phosphorylation of AQP2 at serine 256 is critical ...

    • Essential Role of MFG-E8 for Phagocytic Properties of Microglial Cells 

      Liu, Yong; Yang, Xuesen; Guo, Chenying; Nie, Pan; Liu, Yan; Ma, Jie (Public Library of Science, 2013)
      Milk fat globule factor-E8 (MFG-E8) has been regarded as a key factor involved in the phagocytosis of apoptotic cells. We induced a lentivirus into the microglial cells for the augmentation or abrogation of MFG-E8 expression ...

    • Evidence for Altered Basal Ganglia-Brainstem Connections in Cervical Dystonia 

      Kuster, John K.; Woodman, Sandra C.; Kirlic, Namik; Multhaupt-Buell, Trisha J.; Makris, Nikos; Parent, Martin; Sjalander, Greta; Breiter, Henry; Blood, Anne J.; Makhlouf, Miriam Louise; Sudarsky, Lewis Richard; Breiter, Hans Charles; Sharma, Nutan (Public Library of Science, 2012)
      Background: There has been increasing interest in the interaction of the basal ganglia with the cerebellum and the brainstem in motor control and movement disorders. In addition, it has been suggested that these subcortical ...

    • Right heart failure: toward a common language 

      Mehra, Mandeep R.; Park, Myung H.; Landzberg, Michael J.; Lala, Anuradha; Waxman, Aaron B. (University of Chicago Press, 2013)
      Abstract In this guideline, the International Right Heart Foundation Working Group moves a step forward to develop a common language to describe the development and defects that exemplify the common syndrome of right heart ...

    • An Unbiased Assessment of the Role of Imprinted Genes in an Intergenerational Model of Developmental Programming 

      Radford, Elizabeth J.; Jimenez-Chillaron, Josep; Schroeder, Joshua; Molla, Michael; Andrews, Simon; Didier, Nathalie; Charalambous, Marika; McEwen, Kirsten; Marazzi, Giovanna; Sassoon, David; Ferguson-Smith, Anne C.; Isganaitis, Elvira; Patti, Mary-Elizabeth (Public Library of Science, 2012)
      Environmental factors during early life are critical for the later metabolic health of the individual and of future progeny. In our obesogenic environment, it is of great socioeconomic importance to investigate the mechanisms ...