Browsing Harvard Medical School by Keyword "androgen receptor"

Now showing items 1-5 of 5

    • Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity 

      Yun, Huiyoung; Xie, Jianping; Olumi, Aria F.; Ghosh, Rita; Kumar, Addanki P. (Impact Journals LLC, 2015)
      We provide first-time evidence for ERβ-mediated transcriptional upregulation of c-FLIP as an underlying mechanism in the development of castrate-resistant cancer. While androgens inhibit apoptosis partly through transcriptional ...

    • ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor 

      Mounir, Zineb; Korn, Joshua M; Westerling, Thomas; Lin, Fallon; Kirby, Christina A; Schirle, Markus; McAllister, Gregg; Hoffman, Greg; Ramadan, Nadire; Hartung, Anke; Feng, Yan; Kipp, David Randal; Quinn, Christopher; Fodor, Michelle; Baird, Jason; Schoumacher, Marie; Meyer, Ronald; Deeds, James; Buchwalter, Gilles; Stams, Travis; Keen, Nicholas; Sellers, William R; Brown, Myles; Pagliarini, Raymond A (eLife Sciences Publications, Ltd, 2016)
      The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for functionally relevant ERG interactors, we identify the arginine ...

    • Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism 

      Itkonen, Harri M.; Gorad, Saurabh S.; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone F.; Moestue, Siver A.; Mills, Ian G. (Impact Journals LLC, 2016)
      Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...

    • Loss of Wave1 gene defines a subtype of lethal prostate cancer 

      Sowalsky, Adam G.; Sager, Rebecca; Schaefer, Rachel J.; Bratslavsky, Gennady; Pandolfi, Pier Paolo; Balk, Steven P.; Kotula, Leszek (Impact Journals LLC, 2015)
      Genetic alterations involving TMPRSS2-ERG alterations and deletion of key tumor suppressor genes are associated with development and progression of prostate cancer (PCa). However, less defined are early events that may ...

    • Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation 

      Liu, Xiaming; Han, Weiwei; Gulla, Sarah; Simon, Nicholas I.; Gao, Yanfei; Cai, Changmeng; Yang, Hongmei; Zhang, Xiaoping; Liu, Jihong; Balk, Steven P.; Chen, Shaoyong (Impact Journals LLC, 2016)
      The phosphoprotein phosphatases are emerging as important androgen receptor (AR) regulators in prostate cancer (PCa). We reported previously that the protein phosphatase 1 catalytic subunit (PP1α) can enhance AR activity ...