Now showing items 1-5 of 5

    • Cox-2 Inhibition Enhances the Activity of Sunitinib in Human Renal Cell Carcinoma Xenografts 

      Wang, Xiaoen; Zhang, L; O'Neill, A; Bahamon, B; Alsop, David C.; Mier, James W.; Goldberg, S. Nahum; Signoretti, Sabina; Atkins, M B; Wood, C G; Bhatt, Rupal Satish (Nature Publishing Group, 2013)
      Background: Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2 is a known mediator ...
    • High Dose Intermittent Sorafenib Shows Improved Efficacy Over Conventional Continuous Dose in Renal Cell Carcinoma 

      Wang, Xiaoen; Zhang, Liang; Goldberg, S. Nahum; Bhasin, Manoj; Brown, Victoria; Alsop, David C.; Signoretti, Sabina; Mier, James W.; Atkins, Michael B.; Bhatt, Rupal Satish (BioMed Central, 2011)
      Background: Renal cell carcinoma (RCC) responds to agents that inhibit vascular endothelial growth factor (VEGF) pathway. Sorafenib, a multikinase inhibitor of VEGF receptor, is effective at producing tumor responses and ...
    • Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma 

      Wang, Xiaoen; Solban, Nicolas; Khanna, Prateek; Callea, Marcella; Song, Jiaxi; Alsop, David C.; Pearsall, R. Scott; Atkins, Michael B.; Mier, James W.; Signoretti, Sabina; Alimzhanov, Marat; Kumar, Ravi; Bhasin, Manoj K.; Bhatt, Rupal S. (Impact Journals LLC, 2016)
      Treatment of metastatic renal cell carcinoma (mRCC) with agents that block signaling through vascular endothelial growth factor receptor 2 (VEGFR2) induces disease regression or stabilization in some patients; however, ...
    • Roles for VEGF in the adult 

      Maharaj, Arindel S.R.; D'Amore, Patricia Ann (Elsevier BV, 2007)
      The role of VEGF during development and in pathology is well known, but its function in normal adult tissues is poorly understood. Adverse effects associated with the use of anti-angiogenic therapies targeting VEGF in human ...
    • Vascular channels formed by subpopulations of PECAM1+ melanoma cells 

      Dunleavey, James M.; Xiao, Lin; Thompson, Joshua; Kim, Mi Mi; Shields, Janiel M.; Shelton, Sarah E.; Irvin, David M.; Brings, Victoria E.; Ollila, David; Brekken, Rolf A.; Dayton, Paul A.; Melero-Martin, Juan M.; Dudley, Andrew C. (2014)
      Targeting the vasculature remains a promising approach for treating solid tumors; however, the mechanisms of tumor neovascularization are diverse and complex. Here we uncover a new subpopulation of melanoma cells that ...