Browsing Harvard Medical School by Keyword "birth defects"

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    • Pax3 Stimulates p53 Ubiquitination and Degradation Independent of Transcription 

      Wang, Xiaodan; Morgan, Sarah C.; Loeken, Mary Rose (Public Library of Science, 2011)
      Background: Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac ...