Browsing Harvard Medical School by Keyword "bromodomain"

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    • Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1 

      Jacques, Camille; Lamoureux, François; Baud’huin, Marc; Calleja, Lidia Rodriguez; Quillard, Thibaut; Amiaud, Jérôme; Tirode, Franck; Rédini, Françoise; Bradner, James E.; Heymann, Dominique; Ory, Benjamin (Impact Journals LLC, 2016)
      Ewing Sarcoma is a rare bone and soft tissue malignancy affecting children and young adults. Chromosomal translocations in this cancer produce fusion oncogenes as characteristic molecular signatures of the disease. The ...