Browsing Harvard Medical School by Keyword "cancer biology"
Now showing items 1-5 of 5
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Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis
(Public Library of Science, 2005)Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, ... -
Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo
(Public Library of Science, 2006)Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly ... -
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
(Public Library of Science, 2005)Background: Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of mutations correlates with tumor sensitivity to the ... -
P53 and the defenses against genome instability caused by transposons and repetitive elements
(John Wiley and Sons Inc., 2016)The recent publication by Wylie et al. is reviewed, demonstrating that the p53 protein regulates the movement of transposons. While this work presents genetic evidence for a piRNA‐mediated p53 interaction with transposons ... -
Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling
(Public Library of Science, 2006)Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB functions in an ...