Browsing Harvard Medical School by Keyword "carbon monoxide"

Now showing items 1-6 of 6

    • Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth 

      Nemeth, Zsuzsanna; Csizmadia, Eva; Vikstrom, Lisa; Li, Mailin; Bisht, Kavita; Feizi, Alborz; Otterbein, Sherrie; Zuckerbraun, Brian; Costa, Daniel B.; Pandolfi, Pier Paolo; Fillinger, Janos; Döme, Balazs; Otterbein, Leo E.; Wegiel, Barbara (Impact Journals LLC, 2016)
      We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with ...

    • Estimating the Independent Effects of Multiple Pollutants in the Presence of Measurement Error: An Application of a Measurement-Error–Resistant Technique 

      Zeka, Ariana; Schwartz, Joel David (2004)
      Misclassification of exposure usually leads to biased estimates of exposure–response associations. This is particularly an issue in cases with multiple correlated exposures, where the direction of bias is uncertain. It is ...

    • Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells 

      Wegiel, B; Hedblom, A; Li, M; Gallo, D; Csizmadia, E; Harris, C; Nemeth, Z; Zuckerbraun, B S; Soares, M; Persson, J L; Otterbein, L E (Nature Publishing Group, 2014)
      Critical functions of the immune system are maintained by the ability of myeloid progenitors to differentiate and mature into macrophages. We hypothesized that the cytoprotective gas molecule carbon monoxide (CO), generated ...

    • Methylene Chloride Poisoning in a Cabinet Worker 

      Mahmud, M; Kales, Stefanos Nicholas (National Institute of Environmental Health Sciences, 1999)
      More than a million workers are at risk for methylene chloride exposure. Aerosol sprays and paint stripping may also cause significant nonoccupational exposures. After methylene chloride inhalation, significant amounts of ...

    • Role of the soluble guanylyl cyclase α1/α2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus 

      De Backer, Ole; Elinck, Ellen; Sips, Patrick; Buys, Emmanuel; Brouckaert, Peter; Lefebvre, Romain A. (Springer Nature, 2008)
      Carbon monoxide (CO) has been shown to cause enteric smooth muscle relaxation by activating soluble guanylyl cyclase (sGC). In gastric fundus, the sGCα1β1 heterodimer is believed to be the most important isoform. The aim ...

    • Short-term Effects of Carbon Monoxide on Mortality: An Analysis within the APHEA Project 

      Samoli, Evangelia; Touloumi, Giota; Schwartz, Joel David; Anderson, Hugh Ross; Schindler, Christian; Forsberg, Bertil; Vigotti, Maria Angela; Vonk, Judith; Košnik, Mitja; Skorkovsky, Jiri; Katsouyanni, Klea (National Institute of Environmental Health Sciences, 2007)
      Objectives: We investigated the short-term effects of carbon monoxide on total and cardiovascular mortality in 19 European cities participating in the APHEA-2 (Air Pollution and Health: A European Approach) project. Methods: ...