Browsing Harvard Medical School by Keyword "cardiovascular"

Now showing items 1-11 of 11

    • Cardiovascular-renal complications and the possible role of plasminogen activator inhibitor: a review 

      D'Elia, John A.; Bayliss, George; Gleason, Ray E.; Weinrauch, Larry A. (Oxford University Press, 2016)
      Since angiotensin increases the expression of plasminogen activator inhibitor (PAI), mechanisms associated with an actively functioning renin–angiotensin–aldosterone system can be expected to be associated with increased ...

    • Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index 

      Yang, Albert C.; Tsai, Shih-Jen; Hong, Chen-Jee; Wang, Cynthia; Chen, Tai-Jui; Liou, Ying-Jay; Gaetano, Carlo; Peng, Chung-Kang (Public Library of Science, 2011)
      Background: Genetic polymorphisms in the gene encoding the β-adrenergic receptors (β -AR) have a pivotal role in the functions of the autonomic nervous system. Using heart rate variability (HRV) as an indicator of autonomic ...

    • Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice 

      Vandenwijngaert, Sara; Swinnen, Melissa; Walravens, Ann-Sophie; Beerens, Manu Eddy Maria; Gillijns, Hilde; Caluwé, Ellen; Tainsh, Robert; Nathan, Daniel I.; Allen, Kaitlin; Brouckaert, Peter; Bartunek, Jozef; Scherrer-Crosbie, Marielle; Bloch, Kenneth; Bloch, Donald Bendit; Janssens, Stefan P.; Buys, Emmanuel (Mary Ann Liebert Inc, 2017)
      Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of ...

    • eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE\(^{−/−}\) Mice 

      Ponnuswamy, Padmapriya; Schröttle, Angelika; Ostermeier, Eva; Grüner, Sabine; Huang, Paul Lee; Ertl, Georg; Hoffmann, Ulrich; Nieswandt, Bernhard; Kuhlencordt, Peter J. (Public Library of Science, 2012)
      Background: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme ...

    • Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner 

      Borissoff, Julian I; Otten, Jeroen J. T.; Heeneman, Sylvia; Leenders, Peter; van Oerle, René; Soehnlein, Oliver; Loubele, Sarah T. B. G.; Hamulyák, Karly; Hackeng, Tilman M.; Daemen, Mat J. A. P.; Degen, Jay L.; Weiler, Hartmut; Esmon, Charles T.; van Ryn, Joanne; Biessen, Erik A. L.; Spronk, Henri M. H.; ten Cate, Hugo (Public Library of Science, 2013)
      Background: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published ...

    • Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells 

      Piecewicz, Stephanie M.; Pandey, Ambarish; Roy, Bhaskar; Hua Xiang, Soh; Zetter, Bruce Robert; Sengupta, Shiladitya (Public Library of Science, 2012)
      The ability of embryonic stem cells to differentiate into endothelium and form functional blood vessels has been well established and can potentially be harnessed for therapeutic angiogenesis. However, after almost two ...

    • Intracranial Aneurysm Risk Locus 5q23.2 is Associated with Elevated Systolic Blood Pressure 

      Gaál, Emília Ilona; Salo, Perttu; Kristiansson, Kati; Rehnström, Karola; Kettunen, Johannes; Sarin, Antti-Pekka; Niemelä, Mika; Jula, Antti; Raitakari, Olli T.; Lehtimäki, Terho; Eriksson, Johan G.; Widen, Elisabeth; Günel, Murat; Kurki, Mitja; von und zu Fraunberg, Mikael; Jääskeläinen, Juha E.; Hernesniemi, Juha; Järvelin, Marjo-Riitta; Pouta, Anneli; Salomaa, Veikko; Palotie, Aarno; Perola, Markus; Newton-Cheh, Christopher Holmes (Public Library of Science, 2012)
      Although genome-wide association studies (GWAS) have identified hundreds of complex trait loci, the pathomechanisms of most remain elusive. Studying the genetics of risk factors predisposing to disease is an attractive ...

    • Lead Concentrations in Relation to Multiple Biomarkers of Cardiovascular Disease: The Normative Aging Study 

      Peters, Junenette L.; Kubzansky, Laura Diane; Ikeda, Ai; Fang, Shona C.; Sparrow, David; Weisskopf, Marc G.; Wright, Robert O.; Vokonas, Pantel S; Hu, Howard; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Lead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between ...

    • A Novel Protein Glycan Biomarker and Future Cardiovascular Disease Events 

      Akinkuolie, Akintunde O.; Buring, Julie E.; Ridker, Paul M; Mora, Samia (Blackwell Publishing Ltd, 2014)
      Background: Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N‐acetyl groups, is related to incident cardiovascular disease ...

    • Slit2/Robo4 Signaling Modulates HIV-1 gp120-Induced Lymphatic Hyperpermeability 

      Zhang, Xeufeng; Yu, JinLong; Kuzontkoski, Paula Marie; Zhu, Weiquan; Li, Dean Y.; Groopman, Jerome Elliot (Public Library of Science, 2012)
      Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely ...

    • Testosterone deficiency and cardiovascular mortality 

      Morgentaler, Abraham (Medknow Publications & Media Pvt Ltd, 2015)
      New concerns have been raised regarding cardiovascular (CV) risks with testosterone (T) therapy (TTh). These concerns are based primarily on two widely reported retrospective studies. However, methodological flaws and data ...