Browsing Harvard Medical School by Keyword "zebrafish"
Now showing items 1-11 of 11
-
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling
(eLife Sciences Publications, Ltd, 2015)Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show ... -
BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model
(Nature Publishing Group, 2014)Cerebral arteriovenous malformations (AVMs) are vascular anomalies that carry a high risk of stroke and death. To test potential AVM therapies, a reverse genetics approach was used to model AVMs in zebrafish. Antisense ... -
Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish
(Frontiers Media S.A., 2014)Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based ... -
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
(eLife Sciences Publications, Ltd, 2015)NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 ... -
Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model
(BioMed Central, 2011)The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by ... -
Inhibitors of Neutrophil Recruitment Identified Using Transgenic Zebrafish to Screen a Natural Product Library
(The Company of Biologists, 2013)Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo ... -
Neutrophil-Mediated Experimental Metastasis Is Enhanced by VEGFR Inhibition in a Zebrafish Xenograft Model
(John Wiley & Sons, 2012)Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates tumour invasiveness and micrometastasis by unknown mechanisms. To study the dynamic and reciprocal interactions between tumour ... -
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency
(2012)NOTCH1 pathway activation contributes to the pathogenesis of over 60% of T-cell acute lymphoblastic leukemia (T-ALL). While Notch is thought to exert the majority of its effects through transcriptional activation of Myc, ... -
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain
(eLife Sciences Publications, Ltd, 2016)Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in Nf1-deficient mice is independent of Nf1’s role in down-modulating RAS-MAPK signaling. We demonstrate in zebrafish that nf1 ... -
A zebrafish model of conditional targeted podocyte ablation and regeneration
(2013)Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier. Their depletion plays an important role in the pathogenesis of glomerulosclerosis. Here, ... -
Zebrafish models of cerebrovascular disease
(Nature Publishing Group, 2014)Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a ...