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A Novel Genetic Score Approach Using Instruments to Investigate Interactions between Pathways and Environment: Application to Air Pollution
(Public Library of Science, 2014)
Air pollution has been associated with increased systemic inflammation markers. We developed a new pathway analysis approach to investigate whether gene variants within relevant pathways (oxidative stress, endothelial ...
Brachial Artery Responses to Ambient Pollution, Temperature, and Humidity in People with Type 2 Diabetes: A Repeated-Measures Study
(National Institute of Environmental Health Sciences, 2014)
Background: Extreme weather and air pollution are associated with increased cardiovascular risk in people with diabetes. Objectives: In a population with diabetes, we conducted a novel assessment of vascular brachial artery ...
Short Term Effects of Particle Exposure on Hospital Admissions in the Mid-Atlantic States: A Population Estimate
(Public Library of Science, 2014)
Background: Many studies report significant associations between PM2.5 (particulate matter <2.5 micrometers) and hospital admissions. These studies mostly rely on a limited number of monitors which introduces exposure ...
Structural equation modeling of parasympathetic and sympathetic response to traffic air pollution in a repeated measures study
(BioMed Central, 2013)
Background: Traffic-related air pollution has been associated to a range of adverse health impacts, including decreased heart rate variability (HRV). The association between traffic-related pollution and HRV, however, has ...
Short-Term Changes in Ambient Temperature and Risk of Ischemic Stroke
(S. Karger AG, 2014)
Background: Despite consistent evidence of a higher short-term risk of cardiovascular mortality associated with ambient temperature, there have been discrepant findings on the association between temperature and ischemic ...
Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study
(NLM-Export, 2014)
Background: Few studies have been performed on pulmonary effects of air pollution in the elderly—a vulnerable population with low reserve capacity—and mechanisms and susceptibility factors for potential effects are unclear. ...
Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort
(National Institute of Environmental Health Sciences, 2013)
Background: Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties. Objective: We investigated whether the previously reported ...
The effect of primary organic particles on emergency hospital admissions among the elderly in 3 US cities
(BioMed Central, 2013)
Background: Fine particle (PM2.5) pollution related to combustion sources has been linked to a variety of adverse health outcomes. Although poorly understood, it is possible that organic carbon (OC) species, particularly ...
Predicting DNA methylation level across human tissues
(Oxford University Press, 2014)
Differences in methylation across tissues are critical to cell differentiation and are key to understanding the role of epigenetics in complex diseases. In this investigation, we found that locus-specific methylation ...
Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort
(National Institute of Environmental Health Sciences, 2014)
Background: Exposure to fine particulate matter (PM with diameter ≤ 2.5 μm; PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied. Methods: We studied ...