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Local proliferation dominates lesional macrophage accumulation in atherosclerosis
(2013)
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
(MyJove Corporation, 2009)
Optical projection tomography is a three-dimensional imaging technique that has been recently introduced as an imaging tool primarily in developmental biology and gene expression studies. The technique renders biological ...
A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses
(Public Library of Science, 2007)
The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging ...
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
(Nature Research, 2011)
Coagulase-positive Staphylococcus aureus (S. aureus) is the major causal pathogen of acute endocarditis, a rapidly progressing, destructive infection of the heart valves. Bacterial colonization occurs at sites of endothelial ...
Impaired infarct healing in atherosclerotic mice with Ly-6Chi monocytosis
(Elsevier, 2010)
Objectives: he aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing.Background Monocytes are cellular protagonists of tissue repair, and their specific subtypes ...
Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation
(American Chemical Society, 2009)
The current lack of suitable probes has limited the in vivo imaging of reactive oxygen/nitrogen species (ROS/RNS). ROS/RNS are often generated by ischemia-induced inflammation; defining the extent of tissue involvement or ...
Innate Response Activator B Cells Protect Against Microbial Sepsis
(American Association for the Advancement of Science, 2012)
Recognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B ...
Intra-operative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury
(SAGE Publications, 2010)
Accidental injury to the common bile duct is a rare but serious complication of laparoscopic cholecystectomy. Accurate visualization of the biliary ducts may prevent injury or allow its early detection. Conventional X-ray ...
Angiotensin II drives the production of tumor-promoting macrophages
(Elsevier, 2013)
Macrophages frequently infiltrate tumors and can enhance cancer growth, yet the origins of the macrophage response are not well understood. Here we address molecular mechanisms of macrophage production in a conditional ...
Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
(American Society for Clinical Investigation, 2010)
Rates of graft rejection are high among recipients of heart transplants. The onset and progression of clinically significant heart transplant rejection are currently monitored by serial biopsy, but this approach is highly ...