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Local proliferation dominates lesional macrophage accumulation in atherosclerosis
(2013)
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
(The Rockefeller University Press, 2012)
IL-1b signaling augments continued splenic monocyte supply during acute inflammation.
Myocardial Infarction Accelerates Atherosclerosis
(Nature Publishing Group, 2012)
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...
Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors
(Public Library of Science, 2009)
Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure
(Ovid Technologies (Wolters Kluwer Health), 2016)
Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI remodeling of nonischemic remote myocardium, ...
Lp-PLA 2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative MacrophagesCLINICAL PERSPECTIVE
(Ovid Technologies (Wolters Kluwer Health), 2015)
Background—Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
(American Society for Clinical Investigation, 2007)
Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative ...
Chronic variable stress activates hematopoietic stem cells
(2014)
Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis1,2. While incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking ...
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1
(The Rockefeller University Press, 2015)
Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely ...
Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research
(Elsevier BV, 2016)
Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a ...