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Purification and characterization of heparin-binding endothelial cell growth factors.
(American Society for Biochemistry and Molecular Biology, 1986)
Growth factors are released by mechanically wounded endothelial cells
(Rockefeller University Press, 1989)
Growth factors may be required at sites of mechanical injury and normal wear and tear in vivo, suggesting that the direct action of mechanical forces on cells could lead to growth factor release. Scraping of cells from the ...
Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.
(Proceedings of the National Academy of Sciences, 1988)
Postnatal rat retinal ganglion cells (RGCs) were identified with specific fluorescent labels and placed in culture. Under these conditions, the outgrowth of processes by RGCs was found to be promoted to a far greater degree ...
Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells
(Rockefeller University Press, 1987)
Morphological studies of developing capillaries and observations of alterations in capillaries associated with pathologic neovascularization indicate that pericytes may act as suppressors of endothelial cell (EC) growth. ...
Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wall
(Rockefeller University Press, 1987)
Collagen lattices containing bovine retinal pericytes (RPs), vascular smooth muscle cells (VSMCs), pulmonary microvessel endothelial cells (PMECs), or aortic endothelial cells (AECs) were prepared and contraction was ...
Neurite outgrowth induced by an endothelial cell mitogen isolated from retina
(Rockefeller University Press, 1986)
Retina-derived growth factor (RDGF) is a polypeptide growth factor purified from salt extracts of bovine retinas on the basis of its mitogenic activity for capillary endothelial cells (EC) and BALB/c 3T3 cells. RDGF is ...
Microvascular pericytes contain muscle and nonmuscle actins
(Rockefeller University Press, 1985)
We have affinity-fractionated rabbit antiactin immunoglobulins (IgG) into classes that bind preferentially to either muscle or nonmuscle actins. The pools of muscle- and nonmuscle-specific actin antibodies were used in ...
Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities
(Rockefeller University Press, 1984)
Bovine retina and hypothalamus contain anionic endothelial cell mitogens that display unusual affinities for the negatively charged glycosaminoglycan heparin. Both growth factor activities are acidic polypeptides (pl's of ...
Importance of Size, Sulfation, and Anticoagulant Activity in the Potentiation of Acidic Fibroblast Growth Factor by Hepa
(American Society for Biochemistry and Molecular Biology, 1989)
Heparin was previously reported to potentiate the mitogenic activity of endothelial cell mitogens in a crude extract of bovine hypothalami (Thornton, S. C., Mueller, S. N., and Levine, E. M. (1983) Science 222, 623-625). ...
Demonstration of vasoproliferative activity from mammalian retina
(Rockefeller University Press, 1980)
Vasoproliferative activity has been demonstrated in extracts of retinas from human, bovine, and feline sources. These retinal extracts are capable of stimulating (a) proliferation and thymidine uptake of bovine vascular ...