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Cytological profiling: providing more haystacks for chemists' needles
(BioMed Central, 2005)
Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule
inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of
cellular morphology, followed by ...
The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer
(Springer Science and Business Media LLC, 2009-06-28)
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with ...
The natural history of epilepsy in tuberous sclerosis complex
(Wiley-Blackwell, 2009)
Background: Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease.
Methods: A retrospective chart review of all ...
A Network of Transcriptionally Coordinated Functional Modules in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory, 2005-08-18)
Recent computational and experimental work suggests that functional modules underlie much of cellular physiology and are a useful unit of cellular organization from the perspective of systems biology. Because interactions ...
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
(Springer Science and Business Media LLC, 2008-04-14)
Genetic alterations in the kinase domain of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to treatment with small molecule tyrosine kinase ...
Exploiting Position Effects and the Gypsy Retrovirus Insulator to Engineer Precisely Expressed Transgenes
(Springer Science and Business Media LLC, 2008-03-02)
A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...