Browsing HMS Scholarly Articles by Author "Fukuda, Daiju"

Now showing items 1-3 of 3

    • Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease 

      Aikawa, Elena; Aikawa, Masanori; Libby, Peter; Figueiredo, Jose-Luiz; Rusanescu, Gabriel; Iwamoto, Yoshiko; Fukuda, Daiju; Kohler, Rainer H.; Shi, Guo-Ping; Jaffer, Farouc A.; Weissleder, Ralph (American Heart Association, 2009)
      Background-Clinical studies have demonstrated that 50% of individuals with chronic renal disease (CRD) die of cardiovascular causes, including advanced calcific arterial and valvular disease; however, the mechanisms of ...

    • Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders 

      Fukuda, Daiju; Aikawa, Elena; Swirski, Filip K.; Novobrantseva, Tatiana I.; Kotelianski, Victor; Gorgun, Cem Z.; Chudnovskiy, Aleksey; Yamazaki, Hiroyuki; Croce, Kevin; Weissleder, Ralph; Aster, Jon C.; Hotamisligil, Gökhan S.; Yagita, Hideo; Aikawa, Masanori (National Academy of Sciences, 2012)
      Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory state. Notch signaling regulates tissue development and participates ...

    • PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation 

      Iwata, Hiroshi; Goettsch, Claudia; Sharma, Amitabh; Ricchiuto, Piero; Goh, Wilson Wen Bin; Halu, Arda; Yamada, Iwao; Yoshida, Hideo; Hara, Takuya; Wei, Mei; Inoue, Noriyuki; Fukuda, Daiju; Mojcher, Alexander; Mattson, Peter C.; Barabási, Albert-László; Boothby, Mark; Aikawa, Elena; Singh, Sasha A.; Aikawa, Masanori (Nature Publishing Group, 2016)
      Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that ...