Browsing HMS Scholarly Articles by Author "Yagita, Hideo"

Now showing items 1-4 of 4

    • Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells 

      Tripathi, Sudipta; Chabtini, Lola; Dakle, Pranal J.; Smith, Brian; Akiba, Hisaya; Yagita, Hideo; Guleria, Indira (Public Library of Science, 2015)
      NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines ...

    • Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent 

      Overstreet, Michael G.; Gaylo, Alison; Angermann, Bastian; Hughson, Angela; Hyun, Young-min; Lambert, Kris; Acharya, Mridu; Billroth-Maclurg, Alison C.; Rosenberg, Alexander F.; Topham, David J.; Yagita, Hideo; Kim, Minsoo; Lacy-Hulbert, Adam; Meier-Schellersheim, Martin; Fowell, Deborah J. (2014)
      Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues appears to be integrin-independent actin-myosin based, during inflammation changes to the extracellular ...

    • Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders 

      Fukuda, Daiju; Aikawa, Elena; Swirski, Filip K.; Novobrantseva, Tatiana I.; Kotelianski, Victor; Gorgun, Cem Z.; Chudnovskiy, Aleksey; Yamazaki, Hiroyuki; Croce, Kevin; Weissleder, Ralph; Aster, Jon C.; Hotamisligil, Gökhan S.; Yagita, Hideo; Aikawa, Masanori (National Academy of Sciences, 2012)
      Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory state. Notch signaling regulates tissue development and participates ...

    • The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment 

      Sharma, Madhav D.; Shinde, Rahul; McGaha, Tracy L.; Huang, Lei; Holmgaard, Rikke B.; Wolchok, Jedd D.; Mautino, Mario R.; Celis, Esteban; Sharpe, Arlene H.; Francisco, Loise M.; Powell, Jonathan D.; Yagita, Hideo; Mellor, Andrew L.; Blazar, Bruce R.; Munn, David H. (American Association for the Advancement of Science, 2015)
      The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN ...