Now showing items 1-11 of 11

    • Antibody Avidity in Humoral Immune Responses in Bangladeshi Children and Adults following Administration of an Oral Killed Cholera Vaccine 

      Alam, Mohammad Murshid; Leung, Daniel T.; Akhtar, Marjahan; Nazim, Mohammad; Akter, Sarmin; Uddin, Taher; Khanam, Farhana; Mahbuba, Deena Al; Ahmad, Shaikh Meshbahuddin; Bhuiyan, Taufiqur Rahman; Calderwood, Stephen B.; Ryan, Edward T.; Qadri, Firdausi (American Society for Microbiology, 2013)
      Antibody avidity for antigens following disease or vaccination increases with affinity maturation and somatic hypermutation. In this study, we followed children and adults in Bangladesh for 1 year following oral cholera ...
    • Antigen-Specific Memory B-cell Responses to Enterotoxigenic Escherichia coli Infection in Bangladeshi Adults 

      Alam, Mohammad Murshid; Aktar, Amena; Afrin, Sadia; Rahman, Mohammad Arif; Aktar, Sarmin; Uddin, Taher; Rahman, M. Arifur; Mahbuba, Deena Al; Chowdhury, Fahima; Khan, Ashraful Islam; Bhuiyan, Taufiqur Rahman; Begum, Yasmin Ara; Ryan, Edward T.; Calderwood, Stephen B.; Svennerholm, Ann-Mari; Qadri, Firdausi (Public Library of Science, 2014)
      Background: Multiple infections with diverse enterotoxigenic E. coli (ETEC) strains lead to broad spectrum protection against ETEC diarrhea. However, the precise mechanism of protection against ETEC infection is still ...
    • Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses 

      Leung, Daniel T.; Bhuiyan, Taufiqur R.; Nishat, Naoshin S.; Hoq, Mohammad Rubel; Aktar, Amena; Rahman, M. Arifur; Uddin, Taher; Khan, Ashraful I.; Chowdhury, Fahima; Charles, Richelle C.; Harris, Jason B.; Calderwood, Stephen B.; Qadri, Firdausi; Ryan, Edward T. (Public Library of Science, 2014)
      Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured ...
    • Comparative Proteomic Analysis Reveals Activation of Mucosal Innate Immune Signaling Pathways during Cholera 

      Ellis, Crystal; LaRocque, Regina; Uddin, Taher; Krastins, Bryan; Mayo-Smith, Leslie; Sarracino, David; Karlsson, Elinor; Rahman, Atiqur; Shirin, Tahmina; Bhuiyan, Taufiqur; Chowdhury, Fahima; Khan, Ashraful Islam; Ryan, Edward; Calderwood, Stephen; Qadri, Firdausi; Harris, Jason (American Society for Microbiology, 2015)
      Vibrio cholerae O1 is a major cause of acute watery diarrhea in over 50 countries. Evidence suggests that V. cholerae O1 may activate inflammatory pathways, and a recent study of a Bangladeshi population showed that variants ...
    • Comparison of Immune Responses to the O-Specific Polysaccharide and Lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi Adult Patients with Cholera 

      Johnson, Russell A.; Uddin, Taher; Aktar, Amena; Mohasin, M.; Alam, Mohammad Murshid; Chowdhury, Fahima; Harris, Jason B.; LaRocque, Regina C.; Bufano, Meagan Kelly; Yu, Yanan; Wu-Freeman, Ying; Leung, Daniel T.; Sarracino, David; Krastins, Bryan; Charles, Richelle C.; Xu, Peng; Kováč, Pavol; Calderwood, Stephen B.; Qadri, Firdausi; Ryan, Edward T. (American Society for Microbiology, 2012)
      Immunity against Vibrio cholerae O1 is serogroup specific, and serogrouping is defined by the O-specific polysaccharide (OSP) part of lipopolysaccharide (LPS). Despite this, human immune responses to V. cholerae OSP have ...
    • Immune Responses to the O-Specific Polysaccharide Antigen in Children Who Received a Killed Oral Cholera Vaccine Compared to Responses following Natural Cholera Infection in Bangladesh 

      Leung, Daniel T.; Uddin, Taher; Xu, Peng; Aktar, Amena; Johnson, Russell A.; Rahman, Mohammad Arif; Alam, Mohammad Murshid; Bufano, Meagan Kelly; Eckhoff, Grace; Wu-Freeman, Ying; Yu, Yanan; Sultana, Tania; Khanam, Farhana; Saha, Amit; Chowdhury, Fahima; Khan, Ashraf I.; Charles, Richelle C.; LaRocque, Regina C.; Harris, Jason B.; Calderwood, Stephen B.; Kováč, Pavol; Qadri, Firdausi; Ryan, Edward T. (American Society for Microbiology, 2013)
      Current oral cholera vaccines induce lower levels of protective efficacy and shorter durations of protection in young children than in adults. Immunity against cholera is serogroup specific, and immune responses to Vibrio ...
    • Memory B Cell and Other Immune Responses in Children Receiving Two Doses of an Oral Killed Cholera Vaccine Compared to Responses following Natural Cholera Infection in Bangladesh 

      Leung, Daniel; Rahman, Mohammad Arif; Mohasin, M.; Patel, Sweta; Aktar, Amena; Khanam, Farhana; Uddin, Taher; Riyadh, M. Asrafuzzaman; Saha, Amit; Alam, Mohammad Murshid; Chowdhury, Fahima; Khan, Ashraful Islam; Charles, Richelle; LaRocque, Regina; Harris, Jason; Calderwood, Stephen; Qadri, Firdausi; Ryan, Edward (American Society for Microbiology, 2012)
      Current oral cholera vaccines induce lower protective efficacy and shorter duration of protection against cholera than wild-type infection provides, and this difference is most pronounced in young children. Despite this, ...
    • Mucosal Immunologic Responses in Cholera Patients in Bangladesh 

      Uddin, Taher; Harris, Jason B.; Bhuiyan, Taufiqur Rahman; Shirin, Tahmina; Uddin, Muhammad Ikhtear; Khan, Ashraful Islam; Chowdhury, Fahima; LaRocque, Regina C.; Alam, Nur Haque; Ryan, Edward T.; Calderwood, Stephen B.; Qadri, Firdausi (American Society for Microbiology, 2011)
      Vibrio cholerae O1 causes dehydrating diarrhea with a high mortality rate if untreated. The infection also elicits long-term protective immunity. Since V. cholerae is noninvasive, mucosal immunity is likely important for ...
    • O-Specific Polysaccharide-Specific Memory B Cell Responses in Young Children, Older Children, and Adults Infected with Vibrio cholerae O1 Ogawa in Bangladesh 

      Aktar, Amena; Rahman, M. Arifur; Afrin, Sadia; Faruk, M. Omar; Uddin, Taher; Akter, Aklima; Sami, Israk Nur; Yasmin, Tahirah; Chowdhury, Fahima; Khan, Ashraful; Leung, Daniel; LaRocque, Regina; Charles, Richelle; Bhuiyan, Taufiqur Rahman; Mandlik, Anjali; Kelly, Meagan; Kováč, Pavol; Xu, Peng; Calderwood, Stephen; Harris, Jason; Qadri, Firdausi; Ryan, Edward (American Society for Microbiology, 2016)
      Cholera caused by Vibrio cholerae O1 confers at least 3 to 10 years of protection against subsequent disease regardless of age, despite a relatively rapid fall in antibody levels in peripheral blood, suggesting that memory ...
    • Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh 

      Falkard, Brie; Uddin, Taher; Arifur Rahman, M.; Franke, Molly F.; Aktar, Amena; Uddin, Muhammad Ikhtear; Bhuiyan, Taufiqur Rahman; Leung, Daniel T.; Charles, Richelle C.; Larocque, Regina C.; Harris, Jason B.; Calderwood, Stephen B.; Qadri, Firdausi; Ryan, Edward T. (The American Society of Tropical Medicine and Hygiene, 2015)
      Vibrio cholerae, the cause of cholera, induces both innate and adaptive immune responses in infected humans. Leptin is a hormone that plays a role in both metabolism and mediating immune responses. We characterized leptin ...
    • Vibrio cholerae O1 Infection Induces Proinflammatory CD4+ T-Cell Responses in Blood and Intestinal Mucosa of Infected Humans 

      Kuchta, Alison; Rahman, Taibur; Sennott, Erica L.; Bhuyian, Taufiqur R.; Uddin, Taher; Rashu, Rasheduzzaman; Chowdhury, Fahima; Kahn, Ashraf I.; Arifuzzaman, Mohammad; Weil, Ana A.; Podolsky, Michael; LaRocque, Regina C.; Ryan, Edward T.; Calderwood, Stephen B.; Qadri, Firdausi; Harris, Jason B. (American Society for Microbiology, 2011)
      Vibrio cholerae O1 is a noninvasive enteric pathogen and serves as a model for studies of mucosal immunity. Although symptomatic V. cholerae infection induces durable protection against subsequent disease, vaccination with ...