Browsing HMS Scholarly Articles by Author "Xavier, Ramnik J."

Now showing items 1-8 of 8

    • Discovery of bioactive microbial gene products in inflammatory bowel disease 

      Zhang, Yancong; Bhosle, Amrisha; Bae, Sena; McIver, Lauren J.; Pishchany, Gleb; Accorsi, Emma K.; Thompson, Kelsey N.; Arze, Cesar; Wang, Ya; Subramanian, Ayshwarya; Kearney, Sean M.; Pawluk, April; Plichta, Damian R.; Rahnavard, Ali; Shafquat, Afrah; Xavier, Ramnik J.; Vlamakis, Hera; Garrett, Wendy S.; Krueger, Andy; Huttenhower, Curtis; Franzosa, Eric A. (Springer Science and Business Media LLC, 2022-05-25)
      Microbial communities and their associated bioactive compounds are often disrupted in conditions such as the inflammatory bowel diseases (IBD). However, even in well-characterized environments (e.g. the human gastrointestinal ...

    • Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans 

      Smeekens, Sanne P.; Ng, Aylwin; Kumar, Vinod; Johnson, Melissa D.; Plantinga, Theo S.; van Diemen, Cleo; Arts, Peer; Verwiel, Eugéne T.P.; Gresnigt, Mark S.; Fransen, Karin; van Sommeren, Suzanne; Oosting, Marije; Cheng, Shih-Chin; Joosten, Leo A.B.; Hoischen, Alexander; Kullberg, Bart-Jan; Scott, William K.; Perfect, John R.; van der Meer, Jos W.M.; Wijmenga, Cisca; Netea, Mihai G.; Xavier, Ramnik J. (2013)
      Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here, by integrating transcriptional analysis and functional ...

    • Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease 

      Lipinski, Marta M.; Zheng, Bin; Lu, Tao; Yan, Zhenyu; Py, Bénédicte F.; Ng, Aylwin; Xavier, Ramnik J.; Li, Cheng; Yankner, Bruce A.; Scherzer, Clemens R.; Yuan, Junying (National Academy of Sciences, 2010)
      Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of misfolded proteins, has been implicated in multiple neurodegenerative diseases. However, the mechanisms that lead to the autophagy ...

    • Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution 

      Kang, Joyce B.; Shen, Amber Z.; Gurajala, Saisriram; Nathan, Aparna; Rumker, Laurie; Aguiar, Vitor R. C.; Valencia, Cristian; Lagattuta, Kaitlyn A.; Zhang, Fan; Jonsson, Anna Helena; Yazar, Seyhan; Alquicira-Hernandez, Jose; Khalili, Hamed; Ananthakrishnan, Ashwin N.; Jagadeesh, Karthik; Dey, Kushal; Albrecht, Jennifer; Apruzzese, William; Banda, Nirmal; Barnas, Jennifer L.; Bathon, Joan M.; Ben-Artzi, Ami; Boyce, Brendan F.; Boyle, David L.; Bridges, S. Louis; Bykerk, Vivian P.; Campbell, Debbie; Carr, Hayley L.; Ceponis, Arnold; Chicoine, Adam; Cordle, Andrew; Curtis, Michelle; Deane, Kevin D.; DiCarlo, Edward; Dunn, Patrick; Filer, Andrew; Firestein, Gary S.; Forbess, Lindsy; Geraldino-Pardilla, Laura; Goodman, Susan M.; Gravallese, Ellen M.; Gregersen, Peter K.; Guthridge, Joel M.; Holers, V. Michael; Horowitz, Diane; Hughes, Laura B.; Ishigaki, Kazuyoshi; Ivashkiv, Lionel B.; James, Judith A.; Keras, Gregory; Korsunsky, Ilya; Lakhanpal, Amit; Lederer, James A.; Lewis, Myles; Li, Zhihan J.; Li, Yuhong; Liao, Katherine P.; Mandelin, Arthur M.; Mantel, Ian; Marks, Kathryne E.; Maybury, Mark; McDavid, Andrew; McGeachy, Mandy J.; Mears, Joseph; Meednu, Nida; Millard, Nghia; Moreland, Larry W.; Nayar, Saba; Nerviani, Alessandra; Orange, Dana E.; Perlman, Harris; Pitzalis, Costantino; Rangel-Moreno, Javier; Raza, Karim; Reshef, Yakir; Ritchlin, Christopher; Rivellese, Felice; Robinson, William H.; Sahbudin, Ilfita; Singaraju, Anvita; Seifert, Jennifer A.; Slowikowski, Kamil; Smith, Melanie H.; Tabechian, Darren; Scheel-Toellner, Dagmar; Utz, Paul J.; Watts, Gerald F. M.; Wei, Kevin; Weinand, Kathryn; Weisenfeld, Dana; Weisman, Michael H.; Wyse, Aaron; Xiao, Qian; Zhu, Zhu; Daly, Mark J.; Xavier, Ramnik J.; Donlin, Laura T.; Anolik, Jennifer H.; Powell, Joseph E.; Rao, Deepak A.; Brenner, Michael B.; Gutierrez-Arcelus, Maria; Luo, Yang; Sakaue, Saori; Raychaudhuri, Soumya (Springer Science and Business Media LLC, 2023-11-30)
      The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation, and cancer. While coding variation in HLA genes has been extensively documented, ...

    • Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics 

      Muus, Christoph; Luecken, Malte D.; Eraslan, Gökcen; Sikkema, Lisa; Waghray, Avinash; Heimberg, Graham; Kobayashi, Yoshihiko; Vaishnav, Eeshit Dhaval; Subramanian, Ayshwarya; Smillie, Christopher; Jagadeesh, Karthik A.; Duong, Elizabeth Thu; Fiskin, Evgenij; Torlai Triglia, Elena; Ansari, Meshal; Cai, Peiwen; Lin, Brian; Buchanan, Justin; Chen, Sijia; Shu, Jian; Haber, Adam L.; Chung, Hattie; Montoro, Daniel T.; Adams, Taylor; Aliee, Hananeh; Allon, Samuel J.; Andrusivova, Zaneta; Angelidis, Ilias; Ashenberg, Orr; Bassler, Kevin; Bécavin, Christophe; Benhar, Inbal; Bergenstråhle, Joseph; Bergenstråhle, Ludvig; Bolt, Liam; Braun, Emelie; Bui, Linh T.; Callori, Steven; Chaffin, Mark; Chichelnitskiy, Evgeny; Chiou, Joshua; Conlon, Thomas M.; Cuoco, Michael S.; Cuomo, Anna S. E.; Deprez, Marie; Duclos, Grant; Fine, Denise; Fischer, David S.; Ghazanfar, Shila; Gillich, Astrid; Giotti, Bruno; Gould, Joshua; Guo, Minzhe; Gutierrez, Austin J.; Habermann, Arun C.; Harvey, Tyler; He, Peng; Hou, Xiaomeng; Hu, Lijuan; Hu, Yan; Jaiswal, Alok; Ji, Lu; Jiang, Peiyong; Kapellos, Theodoros S.; Kuo, Christin S.; Larsson, Ludvig; Leney-Greene, Michael A.; Lim, Kyungtae; Litviňuková, Monika; Ludwig, Leif S.; Lukassen, Soeren; Luo, Wendy; Maatz, Henrike; Madissoon, Elo; Mamanova, Lira; Manakongtreecheep, Kasidet; Leroy, Sylvie; Mayr, Christoph H.; Mbano, Ian M.; McAdams, Alexi M.; Nabhan, Ahmad N.; Nyquist, Sarah K.; Penland, Lolita; Poirion, Olivier B.; Poli, Sergio; Qi, CanCan; Queen, Rachel; Reichart, Daniel; Rosas, Ivan; Schupp, Jonas C.; Shea, Conor V.; Shi, Xingyi; Sinha, Rahul; Sit, Rene V.; Slowikowski, Kamil; Slyper, Michal; Smith, Neal P.; Sountoulidis, Alex; Strunz, Maximilian; Sullivan, Travis B.; Sun, Dawei; Talavera-López, Carlos; Tan, Peng; Tantivit, Jessica; Travaglini, Kyle J.; Tucker, Nathan R.; Vernon, Katherine A.; Wadsworth, Marc H.; Waldman, Julia; Wang, Xiuting; Xu, Ke; Yan, Wenjun; Zhao, William; Ziegler, Carly G. K.; Deutsch, Gail H.; Dutra, Jennifer; Gaulton, Kyle J.; Holden-Wiltse, Jeanne; Huyck, Heidie L.; Mariani, Thomas J.; Misra, Ravi S.; Poole, Cory; Preissl, Sebastian; Pryhuber, Gloria S.; Rogers, Lisa; Sun, Xin; Wang, Allen; Whitsett, Jeffrey A.; Xu, Yan; Alladina, Jehan; Banovich, Nicholas E.; Barbry, Pascal; Beane, Jennifer E.; Bhattacharyya, Roby P.; Black, Katharine E.; Brazma, Alvis; Campbell, Joshua D.; Cho, Josalyn L.; Collin, Joseph; Conrad, Christian; de Jong, Kitty; Desai, Tushar; Ding, Diane Z.; Eickelberg, Oliver; Eils, Roland; Ellinor, Patrick T.; Faiz, Alen; Falk, Christine S.; Farzan, Michael; Gellman, Andrew; Getz, Gad; Glass, Ian A.; Greka, Anna; Haniffa, Muzlifah; Hariri, Lida P.; Hennon, Mark W.; Horvath, Peter; Hübner, Norbert; Hung, Deborah T.; Huyck, Heidie L.; Janssen, William J.; Juric, Dejan; Kaminski, Naftali; Koenigshoff, Melanie; Koppelman, Gerard H.; Krasnow, Mark A.; Kropski, Jonathan A.; Kuhnemund, Malte; Lafyatis, Robert; Lako, Majlinda; Lander, Eric S.; Lee, Haeock; Lenburg, Marc E.; Marquette, Charles-Hugo; Metzger, Ross J.; Linnarsson, Sten; Liu, Gang; Lo, Yuk Ming Dennis; Lundeberg, Joakim; Marioni, John C.; Mazzilli, Sarah A.; Medoff, Benjamin D.; Meyer, Kerstin B.; Miao, Zhichao; Misharin, Alexander V.; Nawijn, Martijn C.; Nikolić, Marko Z.; Noseda, Michela; Ordovas-Montanes, Jose; Oudit, Gavin Y.; Pe’er, Dana; Powell, Joseph E.; Quake, Stephen R.; Rajagopal, Jayaraj; Tata, Purushothama Rao; Rawlins, Emma L.; Regev, Aviv; Reid, Mary E.; Reyfman, Paul A.; Rieger-Christ, Kimberly M.; Rojas, Mauricio; Rozenblatt-Rosen, Orit; Saeb-Parsy, Kourosh; Samakovlis, Christos; Sanes, Joshua R.; Schiller, Herbert B.; Schultze, Joachim L.; Schwarz, Roland F.; Segre, Ayellet V.; Seibold, Max A.; Seidman, Christine E.; Seidman, Jon G.; Shalek, Alex K.; Shepherd, Douglas P.; Sinha, Rahul; Spence, Jason R.; Spira, Avrum; Sun, Xin; Sundström, Erik; Teichmann, Sarah A.; Theis, Fabian J.; Tsankov, Alexander M.; Vallier, Ludovic; van den Berge, Maarten; Van Zyl, Tave A.; Villani, Alexandra-Chloé; Weins, Astrid; Xavier, Ramnik J.; Yildirim, Ali Önder; Zaragosi, Laure-Emmanuelle; Zerti, Darin; Zhang, Hongbo; Zhang, Kun; Zhang, Xiaohui (Springer Science and Business Media LLC, 2021-03)
      ACE2 and accessory proteases (TMPRSS2, CTSL) are needed for SARS-CoV-2 cellular entry, and their expression may shed light on viral tropism and impact across the body. We assess the cell type-specific expression of ACE2, ...

    • The Scaffold Protein CNK1 Interacts with the Tumor Suppressor RASSF1A and Augments RASSF1A-induced Cell Death 

      Rabizadeh, Shahrooz; Xavier, Ramnik J.; Ishiguro, Kazuhiro; Bernabeortiz, Juliocesar; Lopez-Ilasaca, Marco; Khokhlatchev, Andrei; Mollahan, Pamela; Pfeifer, Gerd P.; Avruch, Joseph; Seed, Brian (American Society for Biochemistry and Molecular Biology, 2004)
      The connector enhancer of KSR (CNK) is a multidomain scaffold protein discovered in Drosophila, where it is necessary for Ras activation of the Raf kinase. Recent studies have shown that CNK1 also interacts with RalA and ...

    • Transmembrane Adaptor Protein PAG/CBP Is Involved in both Positive and Negative Regulation of Mast Cell Signaling 

      Draberova, Lubica; Bugajev, Viktor; Potuckova, Lucie; Halova, Ivana; Bambouskova, Monika; Polakovicova, Iva; Xavier, Ramnik J.; Seed, Brian; Draber, Petr (American Society for Microbiology, 2014)
      The transmembrane adaptor protein PAG/CBP (here, PAG) is expressed in multiple cell types. Tyrosine-phosphorylated PAG serves as an anchor for C-terminal SRC kinase, an inhibitor of SRC-family kinases. The role of PAG as ...

    • Wnt signaling regulates mitochondrial physiology and insulin sensitivity 

      Yoon, John C.; Ng, Aylwin; Kim, Brian H.; Bianco, Antonio; Xavier, Ramnik J.; Elledge, Stephen J. (Cold Spring Harbor Laboratory Press, 2010)
      Mitochondria serve a critical role in physiology and disease. The genetic basis of mitochondrial regulation in mammalian cells has not yet been detailed. We performed a large-scale RNAi screen to systematically identify ...