Now showing items 1-5 of 5

    • Charge and Hydrophobicity Effects of NIR Fluorophores on Bone-Specific Imaging 

      Bao, Kai; Nasr, Khaled A.; Hyun, Hoon; Lee, Jeong Heon; Gravier, Julien; Gibbs, Summer L.; Choi, Hak Soo (Ivyspring International Publisher, 2015)
      Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose ...
    • Near-Infrared Fluorescence Imaging for Noninvasive Trafficking of Scaffold Degradation 

      Kim, Soon Hee; Lee, Jeong Heon; Hyun, Hoon; Ashitate, Yoshitomo; Park, GwangLi; Robichaud, Kyle; Lunsford, Elaine Patricia; Lee, Sang Jin; Khang, Gilson; Choi, Hak Soo (Nature Publishing Group, 2013)
      Biodegradable scaffolds could revolutionize tissue engineering and regenerative medicine; however, in vivo matrix degradation and tissue ingrowth processes are not fully understood. Currently a large number of samples and ...
    • Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery 

      Wada, Hideyuki; Hyun, Hoon; Vargas, Christina; Gravier, Julien; Park, GwangLi; Gioux, Sylvain; Frangioni, John V.; Henary, Maged; Choi, Hak Soo (Ivyspring International Publisher, 2015)
      Objective: Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas ...
    • Prototype Nerve-Specific Near-Infrared Fluorophores 

      Park, Min Ho; Hyun, Hoon; Ashitate, Yoshitomo; Wada, Hideyuki; Park, GwangLi; Lee, Jeong Heon; Njiojob, Costyl; Henary, Maged; Frangioni, John V.; Choi, Hak Soo (Ivyspring International Publisher, 2014)
      Nerve preservation is an important issue during most surgery because accidental transection or injury results in significant morbidity, including numbness, pain, weakness, or paralysis. Currently, nerves are still identified ...
    • Structure-Inherent Targeting of NIR Fluorophores for Parathyroid and Thyroid Gland Imaging 

      Hyun, Hoon; Park, Min Ho; Owens, Eric A.; Wada, Hideyuki; Henary, Maged; Handgraaf, Hein J.M.; Vahrmeijer, Alexander L.; Frangioni, John V.; Choi, Hak Soo (2014)
      The typical method for creating targeted contrast agents requires covalent conjugation of separate targeting and fluorophore domains. In this study, we demonstrate that it is possible create tissue-specific near-infrared ...