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    • Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan 

      Lamming, Dudley W; Mihaylova, Maria M; Katajisto, Pekka; Baar, Emma L; Yilmaz, Omer H; Hutchins, Amanda; Gultekin, Yetis; Gaither, Rachel; Sabatini, David M (BlackWell Publishing Ltd, 2014)
      Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex ...