Now showing items 1-2 of 2

    • The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells 

      Hamouda, Mohamed-Amine; Belhacene, Nathalie; Puissant, Alexandre; Colosetti, Pascal; Robert, Guillaume; Jacquel, Arnaud; Mari, Bernard; Auberger, Patrick; Luciano, Frederic (Impact Journals LLC, 2014)
      Velcade is one of the inescapable drug to treat patient suffering from multiple myeloma (MM) and resistance to this drug represents a major drawback for patients. However, the mechanisms underlying velcade resistance remain ...
    • SYK Regulates mTOR Signaling in AML 

      Carnevale, Julia; Ross, Linda; Puissant, Alexandre; Banerji, Versha; Stone, Richard M.; DeAngelo, Daniel J.; Ross, Kenneth N.; Stegmaier, Kimberly (2014)
      Spleen Tyrosine Kinase (SYK) was recently identified as a new target in acute myeloid leukemia (AML); however, its mechanistic role in this disease is poorly understood. Based on the known interaction between SYK and mTOR ...