Browsing HMS Scholarly Articles by Author "Castrillon, Diego H."

Now showing items 1-3 of 3

    • Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors 

      Carretero, Julian; Shimamura, Takeshi; Rikova, Klarisa; Jackson, Autumn L.; Wilkerson, Matthew D.; Borgman, Christa L.; Buttarazzi, Matthew S.; Sanofsky, Benjamin A.; McNamara, Kate L.; Brandstetter, Kathleyn A.; Walton, Zandra E.; Gu, Ting-Lei; Silva, Jeffrey C.; Crosby, Katherine; Shapiro, Geoffrey; Maira, Michel; Ji, Hongbin; Castrillon, Diego H.; Kim, Carla; Garcia-Echeverria, Carlos; Bardeesy, Nabeel; Sharpless, Norman E.; Hayes, Neil D.; Kim, William Y.; Engelman, Jeffrey A.; Wong, Kwok-Kin (Elsevier BV, 2010-06-15)
      In mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic ...

    • The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues 

      Nakada, Yuji; Stewart, Thomas G.; Peña, Christopher G.; Zhang, Song; Zhao, Ni; Bardeesy, Nabeel; Sharpless, Norman E.; Wong, Kwok-Kin; Hayes, D. Neil; Castrillon, Diego H. (Public Library of Science, 2013)
      Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and ...

    • Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression 

      Xu, Chunxiao; Fillmore, Christine M.; Koyama, Shohei; Hongbo, Wu; Zhao, Yanqiu; Chen, Zhao; Herter Sprie, Grit; Akbay, Esra A.; Tchaicha, Jeremy; Altabef, Abigail; Reibel, Jacob; Walton, Zandra; Ji, Hongbin; Watanabe, Hideo; Janne, Pasi; Castrillon, Diego H.; Rustgi, Anil K.; Bass, Adam; Freeman, Gordon; Padera, Robert; Dranoff, Glenn; Hammerman, Peter S.; Kim, Carla F.; Wong, Kwok-Kin; Hammerman (Elsevier BV, 2014-05)
      Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, ...