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    • Structural basis of nSH2 regulation and lipid binding in PI3Kα 

      Miller, Michelle S.; Schmidt-Kittler, Oleg; Bolduc, David M.; Brower, Evan T.; Chaves-Moreira, Daniele; Allaire, Marc; Kinzler, Kenneth W.; Jennings, Ian G.; Thompson, Philip E.; Cole, Philip A.; Amzel, L. Mario; Vogelstein, Bert; Gabelli, Sandra B. (Impact Journals LLC, 2014)
      We report two crystal structures of the wild-type phosphatidylinositol 3-kinase α (PI3Kα) heterodimer refined to 2.9 Å and 3.4 Å resolution: the first as the free enzyme, the second in complex with the lipid substrate, ...