Now showing items 1-5 of 5

    • Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions 

      Tam, Jenny M.; Castro, Carlos E.; Heath, Robert John William; Cardenas, Michael L.; Xavier, Ramnik; Lang, Matthew J.; Vyas, Jatin Mahesh (Public Library of Science, 2010)
      The application of live cell imaging allows direct visualization of the dynamic interactions between cells of the immune system. Some preliminary observations challenge long-held beliefs about immune responses to microorganisms; ...
    • Dectin-1 Activation Controls Maturation of β-1,3-Glucan-containing Phagosomes 

      Mansour, Michael Karim; Tam, Jenny M.; Khan, Nida S.; Seward, Michael; Davids, Peter J.; Puranam, Sravanthi; Sokolovska, Anna; Sykes, David Brian; Dagher, Zeina; Becker, Christine; Tanne, Antoine; Reedy, Jennifer L; Stuart, Lynda M.; Vyas, Jatin Mahesh (American Society for Biochemistry & Molecular Biology (ASBMB), 2013)
      Background: Dectin-1 is able to recognize and phagocytose the fungal carbohydrate, β-1,3-glucan, but its contribution to phagosomal maturation has not been explored. Results: Dectin-1-dependent Syk activation promotes ...
    • Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes 

      Klassert, Tilman E.; Hanisch, Anja; Bräuer, Julia; Klaile, Esther; Heyl, Kerstin A.; Mansour, Michael M.; Tam, Jenny M.; Vyas, Jatin M.; Slevogt, Hortense (Springer Berlin Heidelberg, 2014)
      Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to its immunomodulatory effects on both the innate and the adaptive immune ...
    • Risks Associated With Lentiviral Vector Exposures and Prevention Strategies 

      Schlimgen, Ryan; Howard, John; Wooley, Dawn; Thompson, Maureen; Baden, Lindsey R.; Yang, Otto O.; Christiani, David C.; Mostoslavsky, Gustavo; Diamond, David V.; Duane, Elizabeth Gilman; Byers, Karen; Winters, Thomas; Gelfand, Jeffrey A.; Fujimoto, Gary; Hudson, T. Warner; Vyas, Jatin M. (Lippincott Williams & Wilkins, 2016)
      Lentiviral vectors (LVVs) are powerful genetic tools that are being used with greater frequency in biomedical laboratories and clinical trials. Adverse events reported from initial clinical studies provide a basis for risk ...
    • αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells 

      Acharya, Mridu; Sokolovska, Anna; Tam, Jenny M.; Conway, Kara L.; Stefani, Caroline; Raso, Fiona; Mukhopadhyay, Subhankar; Feliu, Marianela; Paul, Elahna; Savill, John; Hynes, Richard O.; Xavier, Ramnik J.; Vyas, Jatin M.; Stuart, Lynda M.; Lacy-Hulbert, Adam (Nature Publishing Group, 2016)
      Integrin signalling triggers cytoskeletal rearrangements, including endocytosis and exocytosis of integrins and other membrane proteins. In addition to recycling integrins, this trafficking can also regulate intracellular ...