Browsing HMS Scholarly Articles by Author "Fadel, Hind J"
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The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
Slaughter, Alison; Jurado, Kellie A; Deng, Nanjie; Feng, Lei; Kessl, Jacques J; Shkriabai, Nikoloz; Larue, Ross C; Fadel, Hind J; Patel, Pratiq A; Jena, Nivedita; Fuchs, James R; Poeschla, Eric; Levy, Ronald M; Engelman, Alan; Kvaratskhelia, Mamuka (BioMed Central, 2014)Background: Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an important new class of anti-HIV-1 agents. ALLINIs bind at the IN catalytic core domain (CCD) dimer interface occupying the principal binding pocket ...