Browsing HMS Scholarly Articles by Author "Zachary, Kimon"
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Diagnosis of Influenza from Lower Respiratory Tract Sampling after Negative Upper Respiratory Tract Sampling
Bogoch, Isaac; Andrews, Jason Randolph; Zachary, Kimon C.; Hohmann, Elizabeth Louise (Landes Bioscience, 2013)In this retrospective cohort study, we demonstrate that PCR-confirmed diagnoses of influenza were made solely by lower respiratory sampling in 6.9% of cases, as traditional upper respiratory tract tests were negative, ... -
The Segment Polarity Gene Porcupine Encodes a Putative Multitransmembrane Protein Involved in Wingless Processing
Kadowaki, Tatsuhiko; Wilder, Elizabeth L.; Klingensmith, John; Zachary, Kimon; Perrimon, Norbert (Cold Spring Harbor Laboratory, 1996-12-15)The Wnt protein Wingless (Wg) functions as a signal in patterning of both the Drosophila embryo and imaginal discs. Lack of porcupine (porc) activity is associated with mutant phenotypes similar to those of wg mutations. ... -
Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows
Lagerborg, Kim A; Normandin, Erica; Bauer, Matthew; Adams, Gordon; Figueroa, Katherine; Loreth, Christine; Gladden-Young, Adrianne; Shaw, Bennett; Pearlman, Leah; Berenzy, Daniel; Dewey, Hannah; Kales, Susan; Dobbins, Sabrina; Seiguer Shenoy, Erica; Hooper, David; Pierce, Virginia; Zachary, Kimon; Park, Daniel; Macinnis, Bronwyn; Tewhey, Ryan; Lemieux, Jacob; Sabeti, Pardis; Reilly, Steven; Siddle, Katherine (Springer Science and Business Media LLC, 2021-12-14)The global spread and continued evolution of SARS-CoV-2 has driven an unprecedented surge in viral genomic surveillance. Amplicon-based sequencing methods provide a sensitive, low-cost and rapid approach but suffer a high ...