Browsing HMS Scholarly Articles by Author "Pyzik, Michal"
Now showing items 1-3 of 3
-
Neonatal Fc receptors for IgG drive CD8+ T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
Baker, Kristi; Rath, Timo; Pyzik, Michal; Blumberg, Richard S (Landes Bioscience, 2014)Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic ... -
Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications
Rath, Timo; Baker, Kristi; Pyzik, Michal; Blumberg, Richard S. (Frontiers Media S.A., 2015)As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation. In addition to these essential homeostatic ... -
The Role of FcRn in Antigen Presentation
Baker, Kristi; Rath, Timo; Pyzik, Michal; Blumberg, Richard S. (Frontiers Media S.A., 2014)Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the ...