Browsing HMS Scholarly Articles by Author "Kyttaris, Vasileios"

Now showing items 1-7 of 7

    • ICER is requisite for Th17 differentiation 

      Yoshida, Nobuya; Comte, Denis; Mizui, Masayuki; Otomo, Kotaro; Rosetti, Florencia; Mayadas, Tanya N.; Crispín, José C.; Bradley, Sean J.; Koga, Tomohiro; Kono, Michihito; Karampetsou, Maria P.; Kyttaris, Vasileios C.; Tenbrock, Klaus; Tsokos, George C. (Nature Publishing Group, 2016)
      Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the ...

    • Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C 

      del Rio, Roxana; McAllister, Ryan D.; Meeker, Nathan D.; Wall, Emma H.; Bond, Jeffrey P.; Kyttaris, Vasileios; Tsokos, George C.; Tung, Kenneth S. K.; Teuscher, Cory (Public Library of Science, 2012)
      Experimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by immunization with autologous testicular homogenate and appropriate ...

    • Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus 

      Wang, Jianxun; Mizui, Masayuki; Zeng, Li-Fan; Bronson, Roderick Terry; Finnell, Michele; Terhorst, Cox; Kyttaris, Vasileios; Tsokos, George C.; Zhang, Zhong-Yin; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2016)
      Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder ...

    • Kinase inhibitors: a new class of antirheumatic drugs 

      Kyttaris, Vasileios (Dove Medical Press, 2012)
      The outlook for patients with rheumatoid arthritis has improved significantly over the last three decades with the use of disease-modifying antirheumatic drugs. However, despite the use of methotrexate, cytokine inhibitors, ...

    • Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling 

      Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C. (Public Library of Science, 2013)
      Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk ...

    • T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus 

      Bradley, Sean J.; Suarez-Fueyo, Abel; Moss, David R.; Kyttaris, Vasileios C.; Tsokos, George C. (Public Library of Science, 2015)
      Background: T cells regulate the adaptive immune response and have altered function in autoimmunity. Systemic Lupus Erythematosus (SLE) has great diversity of presentation and treatment response. Peripheral blood component ...

    • Targeting Syk in Autoimmune Rheumatic Diseases 

      Deng, Guo-Min; Kyttaris, Vasileios C.; Tsokos, George C. (Frontiers Media S.A., 2016)
      Spleen tyrosine kinase (Syk) is a member of the Src family of non-receptor tyrosine kinases, which associates directly with surface receptors, including B-cell receptor and Fcγ receptor, and is involved in a variety of ...