Browsing HMS Scholarly Articles by Author "Calhoun, William J."

Now showing items 1-5 of 5

    • Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma 

      Planaguma, Anna; Kazani, Shamsah; Marigowda, Gautham; Haworth, Oliver; Mariani, Thomas J.; Israel, Elliot; Bleecker, Eugene R.; Curran-Everett, Douglas; Erzurum, Serpil C.; Calhoun, William J.; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Jarjour, Nizar N.; Busse, William W.; Wenzel, Sally E.; Levy, Bruce (American Thoracic Society, 2008-09-15)
      Rationale: Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A4 (LXA4) is an arachidonic acid–derived mediator that serves as an agonist for resolution of ...

    • Asthma Is More Severe in Older Adults 

      Zein, Joe G.; Dweik, Raed A.; Comhair, Suzy A.; Bleecker, Eugene R.; Moore, Wendy C.; Peters, Stephen P.; Busse, William W.; Jarjour, Nizar N.; Calhoun, William J.; Castro, Mario; Chung, K. Fan; Fitzpatrick, Anne; Israel, Elliot; Teague, W. Gerald; Wenzel, Sally E.; Love, Thomas E.; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2015)
      Background: Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods: This is a ...

    • Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma 

      Riley, Craig M.; Wenzel, Sally E.; Castro, Mario; Erzurum, Serpil C.; Chung, Kian Fan; Fitzpatrick, Anne M.; Gaston, Benjamin; Israel, Elliot; Moore, Wendy C.; Bleecker, Eugene R.; Calhoun, William J.; Jarjour, Nizar N.; Busse, William W.; Peters, Stephen P.; Teague, W. Gerald; Sorkness, Ronald; Holguin, Fernando (Public Library of Science (PLoS), 2015-12-30)
      Introduction FEF25-75 is one of the standard results provided in spirometry reports; however, in adult asthmatics there is limited information on how this physiological measure relates to clinical or biological outcomes ...

    • Effect of β2-Adrenergic Receptor Polymorphism on Response to Longacting β2 Agonist in Asthma (LARGE Trial): A Genotype-Stratified, Randomised, Placebo-Controlled, Crossover Trial 

      Wechsler, Michael; Kunselman, Susan J.; Chinchilli, Vernon M.; Bleecker, Eugene R.; Boushey, Homer A.; Calhoun, William J.; Ameredes, Bill T.; Castro, Mario; Craig, Timothy J.; Denlinger, Loren; Fahy, John V.; Jarjour, Nizar; Kazani, Shamsah; Kim, Sophia; Kraft, Monica; Lazarus, Stephen C.; Lemanske, Robert F.; Markezich, Amy; Martin, Richard J.; Permaul, Perdita; Peters, Stephen P.; Ramsdell, Joe; Sorkness, Christine A.; Sutherland, E. Rand; Szefler, Stanley J.; Walter, Michael J.; Wasserman, Stephen I.; Israel, Elliot (Elsevier BV, 2009-11-21)
      Background Combined long-acting β2-agonist and inhaled corticosteroid (LABA/ICS) therapy improves outcomes in many asthmatics. Some studies suggest that patients homozygous for arginine at the 16th amino-acid position of ...

    • Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012 

      Zein, Joe G.; Udeh, Belinda L.; Teague, W. Gerald; Koroukian, Siran M.; Schlitz, Nicholas K.; Bleecker, Eugene R.; Busse, William B.; Calhoun, William J.; Castro, Mario; Comhair, Suzy A.; Fitzpatrick, Anne M.; Israel, Elliot; Wenzel, Sally E.; Holguin, Fernando; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2016)
      Background: Worldwide, asthma is a leading cause of morbidity, mortality and economic burden, with significant gender and racial disparities. However, little attention has been given to the independent role of age on ...