Browsing HMS Scholarly Articles by Author "Exley, Mark"
Now showing items 1-3 of 3
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Defective NKT Cell Activation by CD1d+ TRAMP Prostate Tumor Cells Is Corrected by Interleukin-12 with alpha-Galactosylceramide
Nowak, Michael; Arredouani, Mohammed S.; Tun-Kyi, Adrian; Schmidt-Wolf, Ingo; Sanda, Martin George; Balk, Steven Paul; Exley, Mark Adrian (Public Library of Science, 2010)Numerical and functional defects of invariant natural killer T cells (iNKT) have been documented in human and mouse cancers, resulting in a defect in IFN production in several malignancies. iNKT cells recognize glycolipids ... -
Loss of Effector and Anti-Inflammatory Natural Killer T Lymphocyte Function in Pathogenic Simian Immunodeficiency Virus Infection
Rout, Namita; Greene, Justin; Yue, Simon C.; O'Connor, David; Johnson, R. Paul; Else, James G.; Exley, Mark Adrian; Kaur, Amitinder (Public Library of Science, 2012)Chronic immune activation is a key determinant of AIDS progression in HIV-infected humans and simian immunodeficiency virus (SIV)-infected macaques but is singularly absent in SIV-infected natural hosts. To investigate ... -
Paucity of CD4+ Natural Killer T (NKT) Lymphocytes in Sooty Mangabeys is Associated with Lack of NKT Cell Depletion After SIV Infection
Rout, Namita; Else, James G.; Yue, Simon; Connole, Michelle Ann; Exley, Mark Adrian; Kaur, Amitinder (Public Library of Science, 2010)Lack of chronic immune activation in the presence of persistent viremia is a key feature that distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection in natural hosts from pathogenic SIV and HIV infection. ...