Browsing HMS Scholarly Articles by Author "Qin, Zheng-hong"

Now showing items 1-2 of 2

    • Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes 

      Chen, Lei-lei; Wu, Jun-chao; Wang, Lin-hui; Wang, Jin; Qin, Zheng-hong; Difiglia, Marian; Lin, Fang (Nature Publishing Group, 2012)
      Aim: To investigate the effects of rapamycin on glutamate uptake in cultured rat astrocytes expressing N-terminal 552 residues of mutant huntingtin (Htt-552). Methods: Methods: Primary astrocyte cultures were prepared from ...

    • The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1 

      Wu, Jun-chao; Lin, Fang; Qi, Lin; Wang, Yan; Kegel, Kimberly B; Yoder, Jennifer; Difiglia, Marian; Qin, Zheng-hong (Nature Publishing Group, 2012)
      Aim: Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt. Methods: ...