Browsing HMS Scholarly Articles by Author "Swanson, Kenneth"
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Clinical benefit in recurrent glioblastoma from adjuvant NovoTTF-100A and TCCC after temozolomide and bevacizumab failure: a preliminary observation
Wong, Eric T; Lok, Edwin; Swanson, Kenneth D (BlackWell Publishing Ltd, 2015)The NovoTTF-100A is a device that emits alternating electric fields and it is approved for the treatment of recurrent glioblastoma. It works by perturbing tumor cells during mitosis as they enter anaphase leading to ... -
An Evidence-Based Review of Alternating Electric Fields Therapy for Malignant Gliomas
Wong, Eric T; Lok, Edwin; Swanson, Kenneth D. (Springer US, 2015)Opinion statement Glioblastoma is a deadly disease and even aggressive neurosurgical resection followed by radiation and chemotherapy only extends patient survival to a median of 1.5 years. The challenge in treating this ... -
An Overview of Alternating Electric Fields Therapy (NovoTTF Therapy) for the Treatment of Malignant Glioma
Swanson, Kenneth D.; Lok, Edwin; Wong, Eric T. (Springer US, 2016)As with many cancer treatments, tumor treating fields (TTFields) target rapidly dividing tumor cells. During mitosis, TTFields-exposed cells exhibit uncontrolled membrane blebbing at the onset of anaphase, resulting in ... -
Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit
Gera, Nidhi; Yang, Aaron; Holtzman, Talia S.; Lee, Sze Xian; Wong, Eric T.; Swanson, Kenneth D. (Public Library of Science, 2015)The anti-tumor effects of chemotherapy and radiation are thought to be mediated by triggering G1/S or G2/M cell cycle checkpoints, while spindle poisons, such as paclitaxel, block metaphase exit by initiating the spindle ...