Browsing HMS Scholarly Articles by Author "Czarnecki, Peter"

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    • ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning 

      Czarnecki, Peter G.; Gabriel, George C.; Manning, Danielle K.; Sergeev, Mikhail; Lemke, Kristi; Klena, Nikolai T.; Liu, Xiaoqin; Chen, Yu; Li, You; San Agustin, Jovenal T.; Garnaas, Maija K.; Francis, Richard J.; Tobita, Kimimasa; Goessling, Wolfram; Pazour, Gregory J.; Lo, Cecilia W.; Beier, David R.; Shah, Jagesh V. (2015)
      The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 ...